Peptidoglycan biosynthetic gene murE from Streptococcus pneumoni

Details Peptidoglycan biosynthetic gene murE from Streptococcus pneumoni Peptidoglycan biosynthetic gene murE from Streptococcus pneumoni

1997-03-17

1998-10-13

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

4352523, 4353201, 435325, 536 232, 935 22, 935 66, C12N 900, C12N 120, C12N 1500, C07H 2104

Patent

active

058210962

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the murE stem peptide biosynthetic gene of Streptococcus pneuinoniae. Also provided are vectors and transformed heterologous host cells for expressing the murE enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

REFERENCES:
patent: 5712108 (1998-01-01), Peery et al.
Daniel, Richard A., et al., J. of General Microbiology, 139:361-370 (1993).
Michaud, Catherine, et al., Eur. J. Biochem., 194: 853-861 (1990).
Tao, Jing-Song, et al., Can. J. Microbiol., 35, 1051-1054 (1989).
Jacobs, M.R. (1992) Treatment and Diagnosis of Infections Caused by Drug-Resistant Streptococcus Pheumoniae, Clin. Infect. Dis. 15: 119-127.
Flouret, B., et al., (1981) Reverse-Phase High-Pressure Liquid Chromatography of Uridine Dipohosphate N-Acetylmuramyl Peptide Precursors of Bacterial Cell Wall Peptidoglycan, Anal. Biochem. 114: 59-63.

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