Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1997-03-17
1998-06-23
Wax, Robert A.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435193, 435243, 4352523, 4353201, 435325, 536 232, 935 22, C12N 1500, C12N 910, C12N 500, C07H 2104
Patent
active
057704155
ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murA of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurA enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
REFERENCES:
patent: 5691161 (1997-11-01), Skatrud et al.
J. Marquardt et al., "Cloning and sequencing of E. coli murZ . . . " J. Bacter. 174, 5748-5752 (1992).
E. Brown et al. "MurA(MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis . . . " J. Bacter. 177, 4194-4197 (1995).
Jacobs, M.R. (1992) Treatment and Diagnosis of Infections Caused by Drug-Resistant Streptococcus pneumoniae, Clin. Infect. Dis. 15: 119-127.
Ehrt, S. And Hillen, W. (1994) UDP-N-acetylglucosamine 1-carboxyvinyl-transferase from Acinetobacter calcoaceticus FEMS Microbiol. Lett. 117: 137-142.
Fleischmann, R. D. Et al., (1995) Whole-Genome Random Sequencing and Assmbly of Haemophilus influenzae Rd, Science 269: 496-512.
Wanke, C. et al. (1992) The UDP-Nacetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae, FEBS Letters 301: 271-276.
Trach, K. Et al. (1988) Complete Sequence and Transcriptional Analysis of the spoOF Region of the Bacillus subtilis Chromosome, J. Bacteriology 170: 4194-4208.
Puyet et al. (Jun. 20, 1990) Genetic and structural characterization of EndA a membrane-bound nuclease required for transformation of Streptococcus pneumoniae. J. Molecular Biology 213(4): 727-738.
Peery Robert B.
Skatrud Paul L.
Boone David E.
Eli Lilly and Company
Stole Einar
Wax Robert A.
Webster Thomas D.
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