Peptidodisaccharides as oligosaccharide mimetics

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 172, 536124, 514 25, 514 53, 514 54, C07H 304, C08B 3700

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057567123

ABSTRACT:
Methods are provided to replace the ether oxygen linkage of oligosaccharides with a peptide link, --NHC(O)--, where the nitrogen atom is linked to the anomeric carbon atom of the sugar. A new family of building blocks for combinational synthesis, peptidodisaccharides, is provided containing the peptide linkage. Synthesis is more facile than with the oxygen-linked carbohydrates; the resulting compounds are expected to be more stable to enzymatic and chemical hydrolysis and to be amenable to automated synthesis.

REFERENCES:
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