Peptidic procollagen C-proteinase inhibitors

Details Peptidic procollagen C-proteinase inhibitors Peptidic procollagen C-proteinase inhibitors

2005-10-04

2005-10-04

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

C530S330000, C514S018700, C514S019300

Reexamination Certificate

active

06951918

ABSTRACT:
This invention relates to compounds of Formula (I)wherein R1-R7, A, Z and n are as described in the Summary of the Invention that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for their preparation.

REFERENCES:
patent: 0 084941 (1983-08-01), None
patent: 2762315 (1997-04-01), None
patent: 01 146896 (1989-06-01), None
patent: 08311096 (1996-11-01), None
patent: 09 025293 (1997-01-01), None
patent: WO 92/22523 (1992-12-01), None
patent: WO 95/12612 (1995-05-01), None
patent: WO 96/33176 (1996-10-01), None
patent: WO 97/05865 (1997-02-01), None
patent: WO97/43251 (1997-11-01), None
patent: WO97/49679 (1997-12-01), None
patent: WO98/15525 (1998-04-01), None
patent: WO98/22494 (1998-05-01), None
patent: WO 98/55449 (1998-12-01), None
Fertala, et al.,J. Bio. Chem. vol. 269, pp 11584-11589 (1994), Self-assembly into Fibrils of Collagen II by Enzymic Cleavage of Recombinant Collagen II.
Ewenson, et al.,Eur. J. Med. Chem. vol. 27:3, pp 179-186 (1992), Synthesis and biological activity of peptide hydroxamate inhibitors of degradation of substance P analogues.
Chen, et al.,Bioorg. Med. Chem. Lett., vol. 2:12, pp1685-90 (1992), “One-pot synthesis of cathepsin inhibitors: Nα-protected N-peptidyl-o-acetyl hydroxylamines catalysed by alcalase followed by lipase in anhydrous t-butanol”.
Nikam, et al.,Tetrahedron Letters, vol. 36:2, pp 197-200 (1995), “Synthesis of hydroxamic acids: Pd/BaSO4 as a new catalyst for the deprotection of o-benzyl hydroxamates”.
Laufer, et al.,Eur. Journal of Biochemistry, vol. 150:1 pp 135-140 (1985), “Inhibition of substance P degradation in rat brain preparations by peptide hydroxamic acids”.
Fischer, et al.,Pharmazie, vol. 38:4, pp 249-250 (1983), “N,O-Diacylhydroxylamines as Enzyme-Activated Inhibitors for Serine Proteases”.
Hoffmann, et al.,Journal of Organic Chemistry; vol. 29: pp 748-751 (1964), “A Peptide Synthesis via Hydroxamic Acids”.

Affiliated with

Also associated with

Rating

Peptidic procollagen C-proteinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptidic procollagen C-proteinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptidic procollagen C-proteinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3478652