Peptidic molecules which have been isotopically substituted with

Details Peptidic molecules which have been isotopically substituted with Peptidic molecules which have been isotopically substituted with

1997-09-02

2000-08-29

Weber, Jon P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530350, C07K 200, C07K 113

Patent

active

061110663

ABSTRACT:
Peptidic molecules suitable for three dimensional NMR structure determination are provided which have been substituted with .sup.13 C and/or .sup.15 N in the backbone and/or at the .alpha.-carbon with .sup.2 H but not otherwise in the sidechains of the amino acid residues. One or more amino acids, amino acid species or substantially all of the amino acid residues of the molecule may be so substituted. A method of making the substituted peptidic molecules substituted in this manner is provided.

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