Peptidic ketones as interleukin-1.beta.-converting enzyme inhibi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514311, 514314, 514307, 514336, 514357, 514 18, 514 19, 514444, 514471, 514399, 514365, 514438, 514397, 549 29, 549 60, 549318, 544152, 548204, 5483154, 546147, 546164, 546268, 546329, 530330, 530331, A61K 31535, A61K 3700, C07D40900

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054629390

ABSTRACT:
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R.sub.1 is (CR.sub.5 R.sub.6).sub.n, (CR.sub.5 R.sub.6).sub.n -aryl, (CR.sub.5 R.sub.6).sub.n -heteroaryl, X-(CR.sub.5 R.sub.6).sub.n, X-(CR.sub.5 R.sub.6).sub.n -aryl or X-(CR.sub.5 R.sub.6).sub.n -heteroaryl wherein aryl and heteroaryl may be optionally substituted;

REFERENCES:
patent: 4965283 (1990-10-01), Klessing et al.
patent: 5055451 (1991-10-01), Krantz et al.

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