Peptidic compounds

Details Peptidic compounds Peptidic compounds

2005-09-21

2011-10-18

Bradley, Christina (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S021900

Reexamination Certificate

active

08039430

ABSTRACT:
The present invention provides a compound of formula (I), (II), (III) and (IV) as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and in the treatment of HIV infection. Also provided are pharmaceutical compositions comprising the compounds of the present invention.

REFERENCES:
patent: 5811515 (1998-09-01), Grubbs et al.
patent: 60116700 (1985-06-01), None
patent: WO-03002545 (2003-01-01), None
K. Abiraj et al., “Synthesis of shorter active analogues of Bactenecin7: The effect of change of N-terminal configuration on antimicrobial activity.” Letters in Peptide Science, 9: 283-290, 2002.
Alessandro Tossi et al., “Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity.” Eur. J. Biochem. 250, 549-558, (1997).
Alfredo Rodriguez-Tebar et al., “Thermochemistry of the interaction between peptides and vancomycin or ristocetin,” Journal of Antibiotics, p. 1578-1583, Nov. 1986.
Anderson et al., “Vancomycin, a new antibiotic. IV. Pharmacologic.” Antibiotics annual Journal, 1956-1957, p. 75-81.
Dessen et al., “Crystal Structure of PBP2x from a Highly Penicillin-resistantStreptococcus pneumoniaeClinical Isolate”, The Journal of Biological Chemistry, vol. 276, No. 48, Issue of Nov. 30, pp. 45106-45112, 2001.
Anthony J. Pearson et al., “Studies on the Synthesis of Aryl Ethers Using Arene-Manganese Chemistry”, J. Org. Chem. 1991, 56, 7092-7097.
Chandra T. Miller et al., “The Synthesis and Screening of 1,4,5,8-Naphthalenetetracarboxylic Diimide-Peptide Conjugates with Antibacterial Activity”, Bioorganic & Medicinal Chemistry 9 (2001) 2015-2024.
Charles Ford et al., “In Vivo Activities of U-100592 and U-100766, Novel Oxazolidinone Antimicrobial Agents, against Experimental Bacterial Infections”, Antimicrobial Agents and Chemotherapy, Jun. 1996, p. 1508-1513.
David B. Searls et al., “Using bioinformatics in gene and drug discovery”, DDT vol. 5, No. 4 Apr. 2000.
Dawei Ma et al., “General and Stereospecific Route to 9-Substituted, 8,9-Disubstituted, and 9,10-Disubstituted Analogues of Benzolactam-V8”, J. Org. Chem. 1999, 64, 6366-6373.
Deborah A. Mosca et al., “IB-367, a Protegrin Peptide with in Vitro and in Vivo Activities against the Microflora Associated with Oral Mucositis”, Antimicrobial Agents and Chemotherapy, Jul. 2000, p. 1803-1808.
Donald T. Moir et al., “Genomics and Antimicrobial Drug Discovery”, Antimicrobial Agents and Chemotherapy, Mar. 1999, p. 439-446.
Williams et al., “Structural and Mode of Action Studies on the Antibiotic Vancomycin. Evidence from 270-MHz Proton Magnetic Resonance”, Journal of the American Chemical Society, 99:8 , Apr. 13, 1977.
Williams et al., “Detailed Binding Sites of the Antibiotics Vancomycin and Ristocetin A: Determination of Intermolecular Distances in Antibiotic/Substrate Complexes by Use of the Time-Dependent NOE”, J . Am. Chem. Soc.. vol. 105. No. 5. 1983.
Eranthie Weerapana et al., “Peptides to peptidomimetics: towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase”, Org. Biomol. Chem., 2003, 93-99.
Frederick Marshall et al., “Structure Studies on Vancomycin”, the Lilly Research Laboratories, Indianapolis 6, Indiana, Apr. 20, 1964.
George Eliopoulos et al., “In Vitro Activities of New Oxazolidinone Antimicrobial Agents against Enterococci”, Antimicrobial Agents and Chemotherapy, Jul. 1996, p. 1745-1747.
Wright et al., “D-Alanyl-D-alanine Ligases and the Molecular Mechanism of Vancomycin Resis tance”, Acc. Chem. Res. 1992, 25, 468-473.
Griffith et al., “Vancomycin, a new antibiotic.” J. Antibiotics annual. 1955-1956, 619-622.
Guiot et al., “Isolation of Vancomycin-Resistant Enterococci in Haematologic Patients”, Eur. J. Clin. Microbiol. Infect. Dis., vol. 10, 1991.
Haiyan Lei et al., “Efficient Synthesis of a Phosphinate Bis-Amino Acid and Its Use in the Construction of Amphiphilic Peptides”, J. Org. Chem. 1994,59, 4206-4210.
Hyun-Sik Oh et al., “Development of novel lipid-peptide hybrid compounds with antibacterial activity from natural cationic antibacterial peptides”, Bioorganic & Medicinal Chemistry Letters 14 (2004) 1109-1113.
Gamet et al., “Etude De La Racemisation Induite Par La Dmap Dans les reactions de couplage peptidique”, Tetrahedron vol. 40, No. 11, pp. 1995 to 2001, 1984.
J. Heijenoort et al., “Formation of the glycan chains in the synthesis of bacterial peptidoglycan”, Glycobiology vol. 11, No. 3, pp. 25R-36R, 2001.
Jeffrey Kaplan et al., “The Role of Sugar Residues in Molecular Recognition by Vancomycin”, J. Med. Chem. 2001, 44, 1837-1840.
Jennifer Daly et al., “Mechanism of Action and in Vitro and in Vivo Activities of S-6123, a New Oxazolidinone Compound”, Antimicrobial Agents and Chemotherapy, Sep. 1988, p. 1341-1346.
Jizu Yi et al., “An Inhibitory Monoclonal Antibody Binds at the Turn of the Helix-Turn-Helix Motif in the N-terminal Domain of HIV-1 Integrase”, vol. 275, No. 49, Issue of Dec. 8, pp. 38739-38748, 2000.
John B. Bremner et al., “Synthesis of carbazole-linked cyclic and acyclic peptoids with antibacterial activity”, Tetrahedron 59 (2003) 8741-8755.
Hoffmann et al., “Phylogenetic perspectives in innate immunity” Science, May 21, 1999, 284, 5418; Academic Research Library p. 1313.
Karen Bush et al., “A Functional Classification Scheme for b-Lactamases and Its Correlation with Molecular Structure”, Antimicrobial Agents and Chemotherapy, Jun. 1995, p. 1211-1233.
Konrad Feichtinger et al., “Diprotected Triflylguanidines: A New Class of Guanidinylation Reagents”, J. Org. Chem. 1998, 63, 3804-3805.
Harris et al., “Structure of the Glycopeptide Antibiotic Vancomycin. Evidence for an Asparagine Residue in the Peptide”, J. Am. Chem., Soc, 1982, 104, 4293-4295.
Makoto Kuroda et al., “Whole genome sequencing of meticillin-resistantStaphylococcus aureus”, The Lancet, vol. 357, Apr. 21, 2001.
Matthias Schuster et al., “Olefin Metathesis in Organic Chemistry”, Angew. Chem. Int. Ed. Engl. 1997, 36, 2036-2056.
McCormick et al., “Vancomycin, A New Antibiotic I. Chemical and Biologic Properties ”, Medical Encyclopedia, Inc., New York, NY 1956, p. 606-611.
McGrady et al., “Synthesis of 5-Isopropyl-Substituted Poly(L-proline)s Optically Active cis- and trans-5-lsopropylproline and Poly(cis- and trans-5-Isopropylproline”, Polymer Journal, vol. 19(5):539-555, 1987.
Menno Monnee et al., “Bio-inspired Synthetic Receptor Molecules Towards Mimicry of Vancomycin”, Bioorg. Med. Chem. Lett. 11 (2001) 1521-1525.
Michael Pirrung et al., “Photoremovable Protecting Groups for Phosphorylation of Chiral Alcohols. Asymmetric Synthesis of Phosphotriesters of (−)-3', 5'- Dimethoxybenzoin”, J. Org. Chem. 1994, 59, 3890-3897.
Min Ge et al.,“Vancomycin derivatives that inhibit peptidoglycan biosynthesis without bindin”, Academic Research Library; Apr. 16, 1999; 284, 5413.
Morten B. Strom et al., “Antibacterial activity of 15-residue lactoferricin derivatives”, J. Peptide Res. 56, 2000, 265-274.
Morten B. Strom et al., “Antimicrobial Activity of Short Arginine- and Tryptophan-rich Peptides”, J. Peptide Sci. 8: 431-437 (2002).
Norris E. Allen et al., “Molecular Interactions of a Semisynthetic Glycopeptide Antibiotic with D-Alanyl-D-Alanine and D-Alanyl-D-Lactate Residues”, Antimicrobial Agents and Chemotherapy, Jan. 1997, p. 66-71.
David Payne et al., “The impact of genomics on novel antibacterial targets”, Current Opinion in Drug Discovery and D

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