Peptides with sulfate ester groups

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 15, 530327, 530328, 530329, A61K 3702, C07K 706

Patent

active

050860429

ABSTRACT:
Novel peptides having sulfate ester groups and containing 6 to 9 amino acids; possessing feeding inhibition properties and capable of stimulating the contraction of the gallbladder. Also methods of treating and preventing obesity in which these novel peptides or other specified peptides can be used.

REFERENCES:
patent: 3705140 (1972-12-01), Bernardi et al.
patent: 3839315 (1974-10-01), Ondetti et al.
patent: 3892726 (1975-07-01), Ondetti et al.
patent: 4351829 (1982-09-01), Zetler et al.
patent: 4490364 (1984-12-01), Rivier et al.
patent: 4517180 (1985-05-01), Yanaihara et al.
patent: 4530836 (1985-07-01), Yanaihara et al.
patent: 4769445 (1988-09-01), Comstock et al.
patent: 4808701 (1990-02-01), Danho et al.
J. Med. Chem. 23, pp. 82-85 (1980).
Chemical Abstract 104:225218t (Jun. 23, 1986), abstracting Japanese patent appln. 60/194,000 (Oct. 2, 1985).
Chemical Abstract 102:160854j (May 13, 1985), abstracting Taylor et al., Am. J. Physiol. 248 (3, Pt. 1) (1985).
Chemical Abstract 97:139403e (Oct. 25, 1982), abstracting Stacher et al., Peptides 3 (4)607-12 (1982).
Chem. Abs. 104:184847b (May 26, 1986) abstracting Japanese Patent Application 60/197699 (Oct. 7, 1985).
Chem. Abs. 102:132473r (Apr. 15, 1985), abstracting European Patent Application 124,420 (Nov. 7, 1984).
Chem. Abs. 89:110419p (Sep. 25, 1978), abstracting German Offen. 2,751,016 (Jun. 1, 1978).
Chem. Abs. 97:216686d (Dec. 20, 1982), abstracting Bodanszky et al., Pept., Proc. Eur. Pept. Symp. 16th, 1980 (Pub. 1981) 93-8.
A. Anastasi, et al., "Synthetic Peptides Related to Caerulein, Note, 1", Experientia, 24, pp. 771-773 (1968).
M. A. Ondetti, et al., "CCK-PZ Recent Developments", Digestive Diseases, 15, pp. 149-156 (1970).
J. Pluscec, et al., "Synthesis of Analogs of the C-Terminal Octapeptide of CCK-PZ, Structure-Activity Relationship", J. Med. Chem. 13, pp. 349-352 (1970).
Gibbs, et al., "CCK Decreases Food Intake in Rats", J. Comp. Physiol. Psychol., 84, 488-495 (1973).
Rubin, et al., "Some Biological Characteristics of CCK-PZ and Synthetic Analogs", Nobel Symp., 18, (Front. Gastrointest. Horm. Res.), pp. 41-58 (Pub. 1973).
J. S. Morley, "Structure-Activity Relations in GI Hormones", Nobel Symp., 16, (Front. Gastrointest. Horm. Res.), pp. 143-149 (Pub. 1973).
L. Bernardi, et al., "Synthetic Peptides Related to Caerulein., Note 2", Experientia, 28, pp. 7-9 (1972).
L. Negri, et al., "Action of Caerulein and Caerulein-Like Peptides on `Short-Circuit Current` and Acid Secretion in the Isolated Gastric Mucosa of Amphibians", Naunyn-Schmiedeberg's Arch. Pharmacol., 277, pp. 401-412 (1973).
A. Agosti, et al., "Inhibitory Effects of a Caerulein-Like Peptide on Human Gastric Secretion", European J. Pharmacol., 28, pp. 193-195 (1976).
M. Bodanszky, "CCK-PZ. 4, Synthesis and Properties of a Biologically Active Analog of the C-Terminal Heptapeptide with 2-Amino-6-hydroxyhexanoic Acid (HAhx) Sulfate Replacing Tyrosine Sulfatge", J. Med. Chem., 21, pp. 1030-1035 (1978).
D. Gillessen, et al., "Synthesis and Biological Activity of Methoxinine-Analogs of the C-Terminal Octapeptide of CCK-PZ", Int. J. Peptide Protein Res., 13, pp. 130-135 (1979).
R. D. Meyer, et al., "Biological Activity of the C-Terminal Octapeptide of CCK, of Three of Its Analogs and of Caerulein in the Dog", Experientia, 36, pp. 434-436 (1980).
M. Bodanszky, et al., "CCK-PZ. 5, Hormonally Active Desamino Derivative of TyrSE-Met-Gly-Trp-Met-Asp-Phe-NH.sub.2 ,".
H. M. Rajh, et al., "Tryptophan Replacement in the C-Terminal Octapeptide of CCK-PZ", Int. J. Peptide Protein Res., 15, pp. 200-210 (1980).
M. Bodanszky, et al., "CCK-PZ 6, Synthesis and Properties of the N-Acetyl-derivative of CCK 27-33", Int. J. Peptide Protein Res., 16, pp. 402-411 (1980).
S. M. Anika, et al., "CCK and Satiety in Pigs", Am. J. Physiol. 240 (Regulatory Integrative Comp. Physiol. 9), pp. R310-R318 (1981).
J. Martinez, et al., "Synthesis and Some Pharmacological Properties of Z-TyrSE-Met-Gly-Trp-Met-Asp(Phe-NH.sub.2)-OH, a 32-beta-Aspartyl Analog of CCK-PZ 27-33", J. Med. Chem., 25, pp. 589-593 (1982).
G. Zetler, "Ceruletide, Ceruletide Analogs and CCK-8: Effects on Motor Behavior, Hexobarbital-Induced Sleep and Harman-Induced Confulsions", Peptides, 3, pp. 701-707 (1982).
B. Penke, et al., "Synthesis of Potent Heptapeptide Analogs of CCK", J. Med. Chem., 27, pp. 845-849 (Jul. 1984).
G. Gacel, et al., "Investigation of Receptors Heterogeneity Using CCK-8 Analogs Designed from NMR Studies", In Peptides (1985), pp. 383-385 (publication date, Jan. 30, 1985).
N. Yanaihara, et al., "Synthetic and Structure-function studies on C-terminal Segments of CCK and Gastrin", In Peptides 1985, pp. 373-378 (publicate date, Jan. 30, 1985).
C. Yanaihara, et al., "Dissociation of pancreczymin (PZ) activity from cholecystokinin (CCK) activity of N.alpha-carboxyacyl CCK-7 and CCK-8 analogs with a substituted glycine" Biomed. Res. 6(2), pp. 111-115 (Mar., 1985).
K. Treptow, et al., "Wirkung von Desaminoocta-Pankreczymin auf die lokomoterische Aktivitat von Ratten (The influence of desaminooctapancreczymin on the locomotor activity of rats)", Biomed. Biochim. Acta. 44(10), pp. 1541-1547, (Oct., 1985).
J. Gibbs, et al., "Cholecystokinin Elicits Satiety in Rats with Open Gastric Fistulas", Nature, 245, pp. 323-325 (1973).
Spatola et al., "Backbone Modified CCK Analogs and Their Behavior Toward Proteolytic Enzymes"(Poster), Tenth American Peptide Symposium, May 23-28, 1987, St. Louis, Mo.
J. Rosamond et al., "Structural Requirements for the Satiety Effect of CCK-8", in Peptides; Chemistry and Biology, Proceedings of the Tenth American Peptide Symposium, May 23-28, 1987, St. Louis, Mo., pp. 610-612 (1988).
J. Blosser et al., "Comparative Effects of CCK-8 and Analogs on Anorectic Activity and in vitro Gall Bladder Contractin," (Poster), Society for Neuroscience, Nov. 16-21, 1987, New Orleans, La.
Derwent Abstract 880294147/42, abstracting European Patent Appln. 285,061 (Oct. 5, 1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Peptides with sulfate ester groups does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides with sulfate ester groups, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides with sulfate ester groups will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-348031

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.