Peptides with organo-protective activity

Details Peptides with organo-protective activity Peptides with organo-protective activity

1998-12-02

2001-07-31

Davenport, Avis M. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S015800, C530S326000, C530S327000, C530S328000

Reexamination Certificate

active

06268346

ABSTRACT:

This invention relates to new peptides having high biological activity of the same type as the known natural compound BPC, but with shorter amino acid chains.
BACKGROUND OF THE INVENTION
A biologically active protein with organo-protective activity which was isolated from human or animal matter and named BPC (Body Protecting Compound) was disclosed in EP 0 432 400 and also published: P. Sikiric et al, Exp.Clin. Gastroenterol., 1, 15-26, 1991. This protein has a high molecular weight of about 40 000±5000 Daltons, with an only partially determined structure. This compound has a very broad spectrum of biological activities like: ulcus protective, hepatoprotective, antiviral, antiedematous, general antiinflammation activity, antimalignant activity and others. It should be used in the therapy of cited diseases, further in the therapy of diseases and disorders of nervous system, disorders of dopaminergic etiology, surgery, stomatology, in the curing of infertility and in veterinary medicine. But this broad spectrum of activity can be probably a consequence of undetermined structure or even of insufficiant purity or homogeneity of the isolated compound BPC.
SUMMARY OF THE INVENTION
We have discovered synthetic peptides with only 8 to 15 amino acid residues with a molecular weight between 900 and 1600 Daltons, that have the biological activity of the natural body protecting compound BPC, but with increased selectivity. Our new peptides are more economically produced and are less subject to the effect of side reactions because they contain less amino acid residues than BPC.


REFERENCES:
patent: 0 432 400 A2 (1990-09-01), None
patent: 0 572 688 A1 (1992-05-01), None
Hypothesis: Stomach Stress Response Diagnostic and Therapeutical Value-a New Approach in Organoprotection—Exp Clin Gastroenterol vol. 1, No. 1, pp. 15-16, 1991—Sikiric, et al.
Antiulcerogenic and Anti-Inflammatory Effect of a New Gastric Juice Peptide-body Protection Compound—Exp Clin Gastroenterol vol. 1, No. 1, pp. 17-20 1991—Sikiric, et al.
BPC in Liver Lesions, Exp Clin Gastroenterol vol. 1, No. 1, 1991—Exp Clin Gastroenterol vol. 1, No. 1, pp. 20-21, Sikiric, et al.
BPC Reduced Alloxan-Induced Diabetes Mellitus in Rats, Exp Clin Gastroenterol vol. 1, No. 1, p. 22; 1991—Sikiric, et al.
The Effects of BPC on the Delayed Type Hypersensitivity to 2,4-Dinitrophluorbenzene Demonstrated on Ear and Colon in Mice of NMRI Strain—Exp Clin Gastroenterol vol. 1, No. 1, p. 23; 1991—Sikiric, et al.
Beneficial Effect of a New Gastric Juice Peptide, Body Protection Compound, in Acute Pancreatitis Models, Exp Clin Gastroenterol vol. 1, No. 1, p. 24-25; 1991—Sikiric, et al.
Influence of BPC on Experimental Kidney Lesions Models—Exp Clin Gastroenterol vol. 1, No. 1, p. 25; 1991—Sikiric, et al.
Gastric Mucosal Preventing Effect of Body Protection Compound (BPC) on the Development of Ethanol—and HCl-Induced Gastric Mucosal Injury, Exp Clin Gastroenterol vol. 1, No. 1, pp. 87-90, 1991—Moszic, et al.
Pentadecapeptide BPC 157 Mucosal Protection and Antiinflamatory Effect, Abstract, Supp Gastroenterol, vol. 104-No. 4, Part 2, 1995—Sikiric et al.

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