Peptides with bactericidal activity and endotoxin neutralizing a

Details Peptides with bactericidal activity and endotoxin neutralizing a Peptides with bactericidal activity and endotoxin neutralizing a

1996-05-24

1998-11-03

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 21, 435 697, A61K 3808, A61K 3810, A61K 3817

Patent

active

058308601

ABSTRACT:
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100 amino acids long and have bactericidal and/or endotoxin neutralizing activity. The peptides can be prepared by automated protein synthesis or by recombinant DNA methods. The peptides are useful in methods to treat and prevent bacterial infection in the body and on surfaces. The peptides are also useful to treat endotoxin shock and have endotoxin neutralizing activity.

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