Peptides with an insulin-like action

Details Peptides with an insulin-like action Peptides with an insulin-like action

1994-05-23

1997-04-22

Lukton, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 514 7, 514 8, 514 19, 530331, 530322, A61K 3806

Patent

active

056229348

ABSTRACT:
Peptides with an insulin-like action, of formula I: ##STR1## in which G is a hydrogen atom, an amino add residue, or a monosubstituted or polysubstituted amino acid; D is an amino acid residue, a phosphoamino acid residue, a monosaccharide residue, or a covalent bond; E is --NH--(CH.sub.2).sub.n --NR.sup.5.sub.2, a glycerol residue, or --NH--(CH.sub.2).sub.p --R.sup.6 --R.sup.7 ; R.sup.1 is (C.sub.1 -C.sub.4)-alkyl or .dbd.O; R.sup.2 is a sulfhydryl protecting group, (C.sub.1 -C.sub.3)-alkyl, or a hydrogen atom; R.sup.3 and R.sup.4, independently of one another, are a hydrogen atom or methyl; R.sup.5, each being identical or different, is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; R.sup.6 is O PO.sub.4 H, PO.sub.2 H, NHCOO, S or OCOO; R.sup.7 is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; w is an integer 1 or 2; their preparation and use for treatment of diabetes mellitus or insulin-independent diabetes.

REFERENCES:
patent: 4212796 (1980-07-01), Konig
patent: 4515920 (1985-05-01), Erickson
patent: 4608364 (1986-08-01), Grau
patent: 4701440 (1987-10-01), Grau
patent: 4968696 (1990-11-01), Stehle
patent: 5302582 (1994-04-01), Vertesy
patent: 5461035 (1995-10-01), Mullner
Lehninger, Albert L., Biochemistry, Ch. 10, pp. 249-252, 1975.
Heyliger et al., "Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats," Science, 227:1474-1477 (1985).
Shechter et al., "Insulin-like Stimulation of Glucose Oxidation in Rat Adipocytes by Vanadyl (IV) Ions, Nature", 284:556-58 (1980).
Tamura et al., "A Novel Mechanism for the Insulin-like Effect of Vanadate on Glycogen Synthase in Rat Adipocytes," J. Biol. Chem. 259:6650-58.
Mayerovitch et al., "Oral Administration of Vanadate Normalizes Blood Glucose Levels in Streptozoticin-treated Rats," J. Biol. Chem. 262: 6658-62.
Shisheva et al., "Insulinlike Effects of Zinc Ion In Vitro and In Vivo: Preferential Effects on Desensitized Adipocytes and Induction of Normoglycemia in Streptozocin-Induced Rats," Diabetes, vol. 11.
Asplin et al., "Chiro-Inositol Deficiency and Insulin Resistance: A Comparison of the Chiro-inositol-and the Myo-inositol-containing Insulin Mediators Isolated from Urine, Hemodialysate, and Muscle of Control and type II Diabetic Subjects," Proc. Natl. Acad. Sci., 90:5924-5928 (1993).
Ortmeyer et al., "Chiroinositol Deficiency and Insuln Resistance. II. Acute Effects of D-Chiroinositol Administration in Streptozotocin-Diabetic Rats, Normal Rats Given a Glucose Load, and Spontaneously Insulin-Resistant Rhesus Monkeys," Endocrinology, 132:646-651 (1983).
"Insulin Resistance and Noninsulin-Dependent Diabetes Mellitus: Which Horse Is Pulling the Cart?", W. Timothy Garvey, Diabetes/Metabolism Reviews, 5(8):727-742 (1989).
J.A. Maclaren et al., "The Preparation of Reduced and S-Alkylated Wool Keratins Using Tri-n-Butylphosphine," Aust. J. Chem., 19:2355-2360 (1966).
W. Konig et al., "Saure Abspaltung der S-Tritylgruppe am Beispiel synthetischer Insulinfragmente," Liebigs Ann. Chem., 1979, pp. 227-247.
H. Paulsen, "Advances in Selective Chemical Syntheses of Complex Oligosaccharides," Angewandte Chemie, 21(3):155-224 (Mar. 1982).
R. Schmidt, "New Methods for the Synthesis of Glycosides and Oligosaccharides--Are There Alternatives to the Koenigs-Knorr Method?" Angew. Chem. Int. Ed. Engl., 25:212-235 (1986).
W. Bannwarth et al., "A Simple and Effective Chemical Phosphorylation Procedure for Biomolcules," Helvetica Chimica Acta, 70:175-186 (1987).
C. Murakata et al., "Synthetic Study on Glycophosphatidyl Inositol (GPI) Anchor or Trypanosoma Brucei: Glycoheptaosyl Core," Tetrahedron Letters, 31(17):2439-2442 (1990).
A. Finch, "Theilheimer's Synthetic Methods of Organic Chemistry," Yearbook, 45:VIII-XI, XX-XXIII, 6-9 (1991).

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