Peptides with affinity for a phospholipid and uses

Details Peptides with affinity for a phospholipid and uses Peptides with affinity for a phospholipid and uses

2003-06-30

2010-12-14

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000

Reexamination Certificate

active

07851440

ABSTRACT:
The present invention relates to a peptide for the specific recognition of lipid vectors. The peptide of the invention comprises the peptide sequence (I; SEQ ID NO: 15) below:(I)J1-J2-J3-J4-J5-J6-Z7-U8-J9-J10-U11-Arg-J13-J14-U15-Lys-Gly-X18-Gly-Thr-J21-Glu-J23-J24-U25-J26-J27-J28-U29-J30-J31-Arg-J33-J34-J35-J36-B37-J38-J39-U40-J41-J42-J43-U44-J45-J46-J47-J48-J49-Arg-J51-U52-J53-J54-Asp-U56-Lys-Ser-Z59-Leu-J61-J62-J63-J64-Z65-J66-J67-U68-J69-J70-J71-U72-J73-J74-J75in which the amino acids J are chosen, independently of one another, from essential amino acids, or derivatives thereof, such that at least 50% of them are polar residues chosen from Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr; the amino acids U are chosen, independently of one another, from Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; the amino acid X18is chosen, independently of the other amino acids of the sequence, from Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val; the amino acid B37is chosen, independently of the other amino acids of the sequence, from Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; the amino acid Z7is chosen, independently of the other amino acids of the sequence, from Asp and Gly; the amino acids Z59and Z65are chosen from Glu, Asp, Lys or Arg; and the superscripts of the residues J, Z, U, X and B represent the position of these amino acids in said sequence.

REFERENCES:
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Pierre Montaville, et al., “A new consensus sequence for phosphatidylserine recognition by annexins”, The Journal of Biological Chemistry, vol. 277, No. 27, pp. 24684-24693 Jul. 5, 2002.
Carol L. Sable, et al., “Cloning and functional activity of a novel truncated formed of annexin IV in mouse macrophages”, Biochemical and Biophysical Research Communications, vol. 258, No. 1, pp. 162-167 1999.
Shuang Liu, et al., “99mTc labeling of highly potent small peptides”, Bioconjugate Chem., vol. 8, No. 5, pp. 621-636 1997.
Kanthi P. Pulukkody, et al., “Synthesis of charged and uncharged complexes of gadolinium and yttrium with cyclic polyazaphosphinic acid ligands for in vivo applications”, J. Chem. Soc. Perkin. Trans., vol. 2, pp. 605-620 1993.

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