Peptides with a characteristic antigenic determinant of .alpha.1

Details Peptides with a characteristic antigenic determinant of .alpha.1 Peptides with a characteristic antigenic determinant of .alpha.1

1993-07-22

2000-11-28

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

424 88, 435 792, 435 793, 435 794, 435 795, 436501, 530326, 530327, 530328, 530329, 530392, 530810, 530812, A61K 3900, A61K 3800, G01N 3353, G01N 33566

Patent

active

061531928

ABSTRACT:
A peptide according to the present invention is not more than 40 amino acids long and contains a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 144 and 183 of human .alpha.1-microglobulin or/and a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 1 and 20 of human .alpha.1-microglobulin.
An antibody according to the present invention is capable of specific binding to a peptide according to the present invention as well as to human .alpha.1-microglobulin.
In order to determine human .alpha.1-microglobulin in a sample liquid by an immunoassay, the sample liquid is brought into contact simultaneously or sequentially with defined amounts of the components antibody and peptide whereby one of the components is labelled and the determination is carried out by means of this label.

REFERENCES:
patent: 4636463 (1987-01-01), Altman et al.
patent: 5030565 (1991-07-01), Niman et al.
Van Regenmontal Immunology Today 10(8): 266-272, 1989.
Monroe (1984) "Immunoassay" Analyt. Chem 56 (8) : 921A-931A.
Harlow et al (1988) "Antibodies, A Laboratory Manual" Cold Springs Harbor pp. 128-129.
Babiker-Mohamed et al (Nov., 1991) "Characterical of Monoclonal . . ." Scand. J. Immunol 34:655-666.
Unumeyer et al (1986) "The mRNA for a proteinase . . ."Nucleic Acids Res. 14:7839-7850.
Nilson et al J. Imm. Meth. 99 (1987) 39-45.
Fernandez-Luna J. Imm. Meth. 82 (1985) 101-110.
Vincent et al J. Imm. Meth. 82 (1985) 111-119.
Lerner Nature 299 (1982) 592-596.
Akerstrom et al TIBS 15 (Jun. 1990) 240-243.
Harlow et al Antibodies A Laboratory Manual (1988) pp. 342-343 CSH.
Hemmila Clin. Chem. 31 (1985) 359-370.
Traboni et al., Chem. Abst. 105(19): 166095w (1986).
Postmann et al., Chem. Abst. 114(3): 20507w (1991).
Koyamaishi, Patent Abstracts of Japan 5: 177 (1981).

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