Peptides which stimulate the expression of the cytokines of...

Details Peptides which stimulate the expression of the cytokines of... Peptides which stimulate the expression of the cytokines of...

2005-08-23

2005-08-23

Stucker, Jeffrey (Department: 1648)

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Reexamination Certificate

active

06932973

ABSTRACT:
A pharmaceutical composition for stimulating production of cytokines of inflammation including a peptide corresponding to formula (I) below:in-line-formulae description="In-line Formulae" end="lead"?(A)n-A1-A1-A2-A1-A3-A4-A1-(A)min-line-formulae description="In-line Formulae" end="tail"?in which A is any amino acid, n and m are each whole numbers from 0 to 20 whose sum n+m is between 0 and 20, A1 is a basic amino acid and more particularly lysine (Lys) or arginine (Arg), A2 is an amino acid selected from the group consisting of basic amino acids, glutamic acid (Glu), glycine (Gly) and aspartic acid (Asp), A3 is an amino acid selected from the group consisting of basic amino acids, proline (Pro), glutamic acid (Glu) and glutamine (Gln), A4 is an amino acid selected from the group consisting of basic amino acids, glutamic acid (Glu), glycine (Gly), serine (Ser) and valine (Val), and a pharmaceutically acceptable carrier.

REFERENCES:
patent: 5736294 (1998-04-01), Ecker et al.
patent: 5932218 (1999-08-01), Berzofsky et al.
patent: 6103880 (2000-08-01), Barritault et al.
Horst Ibelgaufts' COPE Cytokine Online Pathfinder Encyclopaedia http://www.copewithcytokines.de/cope.cgi?002632.
Frédéric Jonca et al.,Cell Release of Bioactive Fibroblast Growth Factor 2 by Exon 6-encoded Sequence of Vascular Endothelial Growth Factor, The Journal of Biological Chemistry, vol. 272, No. 39, Sep. 26, 1997, pp. 24203-24209.

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