Peptides which serve as substrates for a phosphokinase and metho

Details Peptides which serve as substrates for a phosphokinase and metho Peptides which serve as substrates for a phosphokinase and metho

1994-10-07

1995-10-17

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530345, 530402, 5303911, C07K 706, C07K 1646

Patent

active

054592402

ABSTRACT:
A method is provided for attaching .sup.32 P to a protein, normally an antibody, that will bind with and irradiate a tumor-associated structure leading to diagnostic benefit. The invention is based upon the introduction of a peptide region to the protein, which is capable of acting as a substrate for a phosphokinase utilizing .sup.32 P-.gamma.-ATP as a typical source of the radionuclide. The conjugation of the substrate molecule to the protein may be achieved by chemical methods or by genetic engineering techniques. Novel substrate peptides are disclosed.

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