Peptides which modulate blood coagulation and methods of use...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S300000

Reexamination Certificate

active

07615527

ABSTRACT:
Peptide fragments that modulate thrombosis and methods of use thereof are provided. Also provided are synthetic bioactive anti-coagulation peptides, compositions comprising such peptides and methods for the administration to patients in need thereof.

REFERENCES:
patent: 4346078 (1982-08-01), Bajusz et al.
patent: 5457090 (1995-10-01), Scott et al.
patent: 5705606 (1998-01-01), Charo et al.
patent: 5858350 (1999-01-01), Vournakis et al.
patent: 2002/0119572 (2002-08-01), Jacobson et al.
patent: WO 98/12318 (1998-03-01), None
Rixon et al. Biochemistry 24: 2077-2086 (1985).
Farrell et al., “Recombinant Human Fibrinogen and Sulfation of the Gamma' Chain”, Biochemistry 30: 9414-9420 (1991).
Collet, J.P., et al., “Influence of γ' Fibrinogen Splice Variant on Fibrin Physical Properties and Fibrinolysis Rate”, Arterioscler. Throm. Vasc. Biol., vol. 24: p. 1-6 (2004).
Farrell, D.H., “Pathophysiologic roles of fibrinogen gamma chain”, Current Opinion in Hematology, vol. 11: pp. 151-155.
Lovely, R.S., et al., “Fibrinogen γ' chain binds thrombin exosite II”, J. of Thrombosis and Haemostasis, vol. 1: 124-131, (2002).
Pospisil, C.H., et al., “Evidence That Both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin”, J. of Biol. Chem., vol. 278: pp. 21584-21591 (2003).
Cooper, A.V., et al., “Fibrinogen gamma-chain splice varient γ' alters fibrin formation and structure”, Blood, vol. 102, pp. 535-540, (2003).
Podor, T.J., et al., “Incorporation of Vitronectin into Fibrin Clots”, J. of Biol. Chem., vol. 277: pp. 7520-7528, (2002).
Lovely, R.S., et al., “Association of γA/γ' Fibrinogen Levels and Coronary Artery Disease”, Thromb. Haemost., vol. 88: pp. 26-31, (2002).
De Bosch, N.B., et al., “Inhibition of Thrombin Generation in Plasma by Fibrin Formation (Antithrombin I)”, Thromb. Haemost., vol. 88: 253-8, (2002).
Meh, D.A., et al., “The Amino Acid Sequence in Fibrin Responsible for High Affinity Thrombin Binding”, Thromb. Haemost., vol. 85: 470-4, (2001).
Dallabrida, S.M., et al., “Factor XIIIa supports microvascular endothelial cell adhesion and inhibits capillary tube formation in fibrin”, Blood, vol. 95: pp. 2586-2592, (2000).
Moaddel, M., et al., “The Role of γA/γ' Fibrinogen in Plasma Factor XIII Activation”, J. of Biological Chemistry, vol. 275: pp. 32135-32140, (2000).
Moaddel, M., et al., “Interactions of Human Fibrinogens with Factor XIII: Roles of Calcium and the γ' Peptide”, Biochemistry, vol. 39: pp. 6698-6705, (2000).
Falls, L.A., et al., “Resistance of γA/γ' Fibrin Clots to Fibrinolysis”, J. of Biological Chemistry, vol. 272: pp. 14251-14256, (1997).
Siebenlist, K.R., et al., “Plasma Factor XIII Binds Specifically to Fibrinogen Molecules Containing γ' Chains”, Biochemistry, vol. 35: pp. 10448-10453, (1996).
Meh, D.A., et al., “Identification and Characterization of the Thrombin Binding Sites on Fibrin”, J. of Biological Chemistry, vol. 271: pp. 32121-32125, (1996).
Hofsteenge, J. “The effect of substituting phosphotyrosine for sulphtyrosine on the activity of hirudin”; Eur. J. Biochem., 188: 55-59(1990).
Hortin, G.L., et al., “Inhibition of thrombin's clotting activity by synthetic peptide segments of its inhibitors and substrates,” Biochem. Biophys. Res. Comm., 169(2):437-442, (Jun. 15, 1990).
Farrell, D.H., “Pathophysiologic roles of fibrinogen gamma chain”, Current Opinion in Hematology, vol. 11: pp. 151-155, 2004.

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