Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-04-19
2011-04-19
Spector, Lorraine (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S300000, C435S007200, C435S007800
Reexamination Certificate
active
07927813
ABSTRACT:
The invention relates to a method of screening and identifying modulators of the protein interaction between new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with cancer in order to bring about apoptotic-type and/or autophagic-type programmed cell death in those patients.
REFERENCES:
patent: 7459434 (2008-12-01), Geneste et al.
patent: 7582439 (2009-09-01), Cory et al.
patent: 7588914 (2009-09-01), Godzik et al.
patent: 7723469 (2010-05-01), Walensky et al.
Ninkina et al., Cerd4, third member of the d4 gene family: expression and organization of genomic locus, Mamm. Genome, 12(11):862-866, 2001.
Oltersdorf et al., An inhibitor of Bcl-2 family proteins induces regression of solid tumours, Nature, 435:667-681, Jun. 2, 2005.
Delft et al., The BH3 mimetic ABT-737 targest selective Bcl-2 proteins and efficiently induced apoptosis via Bak/Bax if Mcl-1 is neutralized, Cancer Cell, 10:389-399, Nov. 2006.
J.A. Parsons, Peptide Hormones (University Park Press: Baltimore), pp. 1-7, 1976.
T.E. Creighton, PROTEINS: Structure and molecular principles (W.H. Reeman & Co.: New York), pp. 223-227, 1984.
Walensky et al., Activation of Apoptosis in vivo by a hydrocarbon-stapled BH3 helix, Science 305:1466-1470, 2004.
Viera et al., Pro-apoptotic BH3 peptides, Oncogene 21:1963-1977, 2002.
Database EMBL, Jun. 18, 1998, “Rattus norvegicus BcI-2 related orvarian death gene product BOD mNRA, Complete CDS.” XP002355353, Accession No. EM—PRO:AF065431.
Database UniProt, Nov. 1, 1997, “Zinc-finger protein DPF2 (cer-d4)” XP002355352, Accession No. Q92784.
Database UnitProt, Oct. 25, 2004, “HECT, UBA and WWE domain containing protein 1(E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1)” XP002355987, Accession No. Q7Z6Z7.
Database UniProt, Mar. 29, 2004, “DNA replication complex GINS protein PSF2” XP002355988, Accession No. Q9Y248.
Database UniProt, Jul. 5, 2004, “Mineral dust induced gene protein 2” XP002355989, Accession No. Q6SKSO.
Ottilie S. et al., “Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins”, Journal of Biological Chemistry, vol. 272, No. 49, p. 30866-30872, Dec. 5, 1997.
Inohara N., et al., “Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X1” EMBO Journal, vol. 16, No. 7, p. 1686-1694, Apr. 1997.
Wang K. et al., “BID: A novel BH3 domain-only death agonist” Genes and Development, vol. 10, No. 22, p. 2859-2869, Nov. 15, 1996.
Boyd J.M., et al., “BIK, A novel death inducing protein shares a distinct sequence motif with bel-2 family proteins and interacts with viral and cellular survival-promoting proteins”, Oncogene, Basingstoke, Hants, vol. 11, No. 9, p. 1921-1928, Nov. 2, 1995.
Cory Suzanne, et al., “The Bc12 family: regulators of the cellular life-or-death switch” Nature Reviews Cancer, vol. 2, No. 9, p. 647-656, Sep. 2002.
Owicki J.C., “Fluorescence polarization and anisotropy in high throughput screening: Perspectives and primer” Journal of Biomolecular Screening, vol. 5, No. 5, p. 297-306, Oct. 2000.
French Preliminary Search Report for FR0500978 of Nov. 25, 2005.
International Search Report for PCT/FR2006/000206 of Sep. 18, 2006.
Geneste Olivier
Hickman John
Rain Jean-Christophe
Hueschen and Sage
Hybrigenics
Kaufman Claire
Les Laboratories Servier
Spector Lorraine
LandOfFree
Peptides which interact with anti-apoptotic members of the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptides which interact with anti-apoptotic members of the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides which interact with anti-apoptotic members of the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2626992