Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1996-06-28
1998-11-03
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
530384, C07K 700
Patent
active
058310037
ABSTRACT:
Peptide ligands which bind to thrombin and prothrombin are disclosed. The sequences of these peptides are Gln-Leu-Trp-Gly-Ser-His, Arg-Gln-Leu-Trp-Gly-Ser-His, His-Gln-Leu-Trp-Gly-Ser-His, and Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. The preferred peptides have the sequence Gln-Leu-Trp-Gly-Ser-His or Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. A method of using these peptides in an affinity chromatography process to purify thrombin is described.
REFERENCES:
patent: 5367060 (1994-11-01), Vanalen et al.
Baumbach George A.
Buettner Joseph A.
Dadd Christopher A.
Hammond David J.
Bayer Corporation
Beck Michael J.
Delacroix-Muirheid C.
Giblin James A.
Tsang Cecilia J.
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