Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Patent
1995-12-13
1998-09-15
Grimes, Eric
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
530328, 530345, 530409, 530410, A61K 3804, A61K 3800, C07K 100
Patent
active
058079815
ABSTRACT:
The present invention is directed to the isolation and identification of the nucleic acid sequence encoding C-proteinase, the recognition of such protein's activity and applications, and tools, processes, and methods of use thereof. The invention is further directed to the identification of molecules modulating C-proteinase's activity, and methods, processes and tools therefor. In a more specific aspect, the invention is directed to peptides resembling the C-proteinase recognition site of procollagen. Such peptides may be employed as modulators of C-proteinase activity, by, for example, acting as competitive inhibitor, and may be employed for the treatment of disorders which involve unregulated production of collagen. Furthermore, such peptides may be employed as C-proteinase substrates for screening of molecules to identify compounds which modulate C-proteinase's activity.
REFERENCES:
patent: 4640893 (1987-02-01), Mangel et al.
patent: 4877864 (1989-10-01), Wang et al.
patent: 5108922 (1992-04-01), Wang et al.
Methods in Enzymol. 153:516-544.
Bond and Beynon, 1995, "The astacin family of metalloendopeptidases", Protein Science 4:1247-1261.
Bornstein and Traub, 1979, in: The Proteins (eds. Neurath, H. and Hill, R.H.), Academic Press, New York, pp. 412-632.
Brisson et al., 1984, "Expressions of a bacterial gene in plants by using a viral vector", Nature 310:511-514.
Broglie et al., 1984, "Light-Regulated Expression of a Pea Ribulose-1,5-Bisphosphate Carboxylase Small Subunit Gene in Transformed Plant Cells", Science 224:838-843.
Caruthers et al., 1980, "New chemical methods for sythesizing polynucleotides", Nucleic Acids Res. Symp. Ser. 7:215-233.
Chow et al., 1981, "Synthesis of oligodeoxyribonucleotides on silica gel support", Nucleic Acids Res. 9:2807-2817.
Colberre-Garapin et al., 1981, "A New Dominant Hybrid Selective Marker for Higher Eukaryotic Cells", J. Mol. Biol. 150:1.
Coruzzi et al., 1984, "Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate Carboxylase", EMBO J. 3:1671-1680.
Crea and Horn, 1980, "Synthesis of oligonucleotides on cellulose by a phosphotriester method", Nucleic Acids Res. 9:2331.
Davidson et al., 1979, "Procollagen Processing: Limited Proteolysis of COOH-Terminal Extension Peptides by a Cathepsin-Like Protease Secreted by Tendon Fibroblasts", Eur. J. Biochem. 100:551.
Duskin et al., 1978, "The Role of Glycosylation in the Enzymatic Conversion of Procollagen to Collagen: Studies Using Tunicamycin and Concanavalin A", Arch. Biochem. Biophys. 185:326-332.
Fessler and Fessler, 1978, "Biosynthesis of Procollagen", Annu. Rev. Biochem. 47:129-162.
Fukagawa et al, 1994, "Embryonic Expression of Mouse Bone Morphogenetic Protein-1 (BMP-1), Which is Related to the Drosophila Dorsoventral Gene tolloidand Encodes a Putative Astacin Metalloendopeptidase", Developmental Biology 163:175-183.
Goldberg et al., 1975, "Procollagen Peptidase: Its Mode of Action on the Native Substrate", Cell 4:45-50.
Gurley et al., 1986, "Upstream Sequences Required for Efficient Expression of a Soybean Heat Shock Gene",Mol. Cell. Biol. 6:559-565.
Hartman and Mulligan, 1988, "Two dominant-acting selectable markers for gene transfer studies in mammalian cells", Proc. Natl. Acad. Sci. USA 85:8047.
Hojima et al., 1985, "Type I Procollagen Carboxyl-terminal Proteinase from Chick Embryo Tendons--Purication and Characterization", J. Biol. Chem. 260:15996-16003.
Inouye and Inouye, 1985, "Up-promoter mutations in the Ipp gene of Escherichia coli ", Nucleic Acids Res. 13:3101-3109.
Kessler and Goldberg, 1978, "A Method for Assaying the Activity of the Endopeptidase Which Excises the Nonhelical Carbozyterminal Extensions from Type I Procollagen", Anal. Biochem. 86:463-469.
Kessler and Adar, 1989, "Type I procollagen C-proteinase from mouse fibroblasts: Purification and demonstration of a 55-k Da enhancer glycoprotein", Eur. J. Biochem. 186:115-121.
Kessler et al., 1986, "Partial Purification and Characterization of a Procollagen C-Proteinase from the culture Medium of Mouse Fibroblasts", Collagen Relat. Res. 6:249-266.
Kivirikko et al., 1984, in: Extracellular Matrix Biochemistry (eds. Piez, K.A. and Reddi, A.H.), Elsevier Science Publishing Co., Inc., New York, pp. 83-118.
Kuhn, 1987, in: Structure and Function of Collagen Types (eds. Mayne, R. and Burgeson, R.E.), Academic Press, Inc., Orlando, Fl., pp. 1-42.
Leung et al., 1979, "Separate Amino and Carboyxl Procollagen Peptidases in Chick Embryo Tendon", J. Biol. Chem. 254:224-232.
Logan and Shenk, 1984, "Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection", Proc. Natl. Acad. Sci. USA 81:3655-3659.
Lowy et al., 1980, "Isolation of Transforming DNA: Cloning the Hamster aprt Gene", Cell 22:817.
Mackett et al., 1984, "General Method for Production and Selection of Infectious Vaccinia Virus Recombinants Expressing Foreign Genes", J. Virol. 49:857-864.
Mackett et al., 1982, "Vaccinia virus: A selectable eukaryotic cloning and expression vector", Proc. Natl. Acad. Sci. USA 79;7415-7419.
Matteucci and Caruthers, 1980, "The Synthesis Of Oligodeoxypyrimidines On A Polymer Support", Tetrahedron Letters 21:719.
Miyazono et al, 1988, "Latent High Molecular Weight Complex of Tranforming Growth Factor .beta.1 Purification from Human Platelets and Structural Characterization", J. Biol. Chem. 263:6407.
Mulligan and Berg, 1981, "Selection for animal cells that expresses the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase", Proc. Natl. Acad. Sci. USA 78:2072.
Ngyen et al., 1994, "Characterization of tolloid-related-1: A BMP-1-like Product That Is Required during Larval and Pupal Stages of Drosophila Development", Developmental Biology 166: 569-586.
Njieha et al., 1982, "Partial Purification of a Procollagen C-Proteinase. Inhibition by Synthetic Peptides and Sequential Cleavage of Type I Procollagen", Biochemistry 21:757-764.
O'Hare et al., 1981, "Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase", Proc. Natl. Acad. Sci. USA 78:1527.
Panicali and Paoletti, 1982, "Construction of poxviruses of cloning vectors: Insertion of the thymidine kinase gene from herpe simplex virus into the DNA of infections vaccinia virus", Proc. Natl. Sci. USA 79:4927-4931.
Prockop and Kivirikko, 1984, "Heritable Diseases of Collagen", N. Engl. J. Med. 311:376-383.
Ruther and Muller-Hill, 1983, "Easy identification of cDNA clones", EMBO J. 2:1791.
Ryhanen et al., 1982, "Conversion of Type II Procollagen to Collagen in Vitro: Removal of the Carboxy-Terminal Extension Is Inhibited by Several Naturally Occuring Amino Acids, Polyamines, and Structurally Related Compounds", Arch. Biochem. Biophys. 215:230-236.
Santerre et al., 1984, "Expression of prokaryotic genes for hygromycin B and G418 resistance as dominant-selection markers in mouse L cells", Gene 30:147-156.
Smith et al., 1983, "Molecular Engineering of the Autographa californica Nuclear Polyhedrosis Virus Genome: Deletion Mutations Within the Polyhedrin Gene", J. Viol. 46:584-593.
Szybalska and Szybalski, 1962, "Genetics of Human Cell Lines, IV. DNA-Mediated Heritable Transformation of a Biochemical Trait", Proc. Natl. Acad. Sci. USA 48:2026-2034.
Takahara et al., 1994, "Type I Procollagen COOH-terminal Proteinase Enhancer Protein: Identification, Primary Structure, and Chromosomal Locatization of the Cognate Human Gene (PCOLCE)", J. Biol. Chem. 269:26280-26285.
Takamatsu et al., 1987, "Expression of bacterial Chloramphenicol acetyltransferase gene in tobacco mediated by TMV-RNA", EMBO J. 6:307-311.
Titany et al., 1987, "Amino Acid Sequence of a Unique Protease from the Crayfish Astacus fluviatillis", Biochemistry 26:222-226.
Van Heeke and Schuster, 1989, "Expression of Human Asparagine Synthetase in Escherichia coli", J. Biol. Chem. 264:5503-5509.
Wigler et al., 1977, "Transfer of Purified Herpes Virus Thymidine Kinase Gene to Cultured Mouse Cells", Cell 11:223-232.
Wigler et al., 1980, "Transformation of mammal
FibroGen Inc.
Grimes Eric
Slobodyansky Elizabeth
LandOfFree
Peptides which are cleaved by C-proteinase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptides which are cleaved by C-proteinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides which are cleaved by C-proteinase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-88660