Peptides useful as tachykinin agonists

Details Peptides useful as tachykinin agonists Peptides useful as tachykinin agonists

1992-12-17

1994-07-19

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530323, 530327, 530329, C07K 754, C07K 706, C07K 708

Patent

active

053310896

ABSTRACT:
A class of monomeric or dimeric peptides containing a specific hexa- or heptapeptide unit in either linear or cyclic form are active tachykinin antagonists and are therefore useful in disease states in which these peptides have been implicated, such as allergic conditions, inflammation, migraine, arthritis and CNS disorders.

REFERENCES:
patent: 4501733 (1985-02-01), Horig et al.
patent: 4665157 (1987-05-01), Wright
patent: 4680283 (1987-07-01), Veber et al.
Aldrich-Catalog Handbook of Fine Chemicals, p. 1177 1986 Aldrich Chemical Co.
Rudinger, Peptide Hormones, Parsons (Ed.) U. Park Press, Baltimore, pp. 1-7 (1976).
Cascieri et al., Molecular Pharmacology, vol. 29, pp. 34-38 (1986).
Kirk-Othmer, Encyclopedia of Chemical Technology (New York, John Wiley and Sons), 3rd Ed., vol. 2, p. 809 (1978).

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