Peptides that inhibit von Willebrand Factor binding to the plate

Details Peptides that inhibit von Willebrand Factor binding to the plate Peptides that inhibit von Willebrand Factor binding to the plate

1990-05-07

1993-08-24

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514822, 530324, 530325, 530326, 530383, 530395, A61K 3516, A61K 3702, C07K 408, C07K 1514

Patent

active

052389197

ABSTRACT:
This invention provides a peptide fragment of human von Willebrand Factor (vWF) and sub-fragment thereof isolated as enzymtic digestion products from naturally occurring human vWF, or isolated from synthetic peptide mixtures or isolated from lysates of organisms capable of producing recombinant human vWF. The fragments and sub-fragments are useful in the prevention and treatment of cardiovascular disorders by virtue of their ability to inhibit the binding of vWF to platelets, heparin and/or collagen.

REFERENCES:
patent: 4683291 (1987-07-01), Zimmerman et al.
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Watson et al., Mol. Biol. of the Gene, 4th ed., Benjamin/Cummings Publishing Co. p. 46 (1987).
Pierschbacher et al., Nature, vol. 309, pp. 30-33 (1984).
Fujimura et al., The Journal of Biological Chemistry vol. 261, No. 1, pp. 381-385, 1986.
Rudinger, Peptide Hormones, pp. 1-7, Parsons (ed.), U Park Press, Baltimore (1976).
Creighton, Proteins, W. H. Freeman and Co., New York, pp. 25-27, 29-30, 33, 35, 37-42, 50, 100 (1983).
Lewin, Genes, 2nd ed., John Wiley & Sons, pp. 189, 282-293, 1985.
Concise Encyclopedia of Biochemistry, Walter de Gruyten, Berlin, New York p. 331 (1983).
Fujimura et al., J. Biol. Chem., vol. 262, No. 4, pp. 1734-1739, 1987.
Mohri et al., J. of Biol. Chem., vol. 263, No. 34, pp. 17901-17904, 1988.
Mohri et al., J. of Biol. Chem., vol. 264, No. 29, pp. 17361-17367, 1989.

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