Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-26
1997-05-06
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530327, 530328, 530329, 530330, 4241881, G01N 3353, A61K 3921, C07K 500, C07K 1600
Patent
active
056270356
ABSTRACT:
It has now been found that relatively short peptides such as the tripeptide glycyl-prolyl-glycine are able to effectively inhibit HIV infection of cells and syncytia formation between HIV infected and and non-infected cells. The peptides are suitable for therapy of patients infected with HIV and in prevention of HIV infection.
REFERENCES:
patent: 4612337 (1986-09-01), Fox et al.
patent: 4818540 (1989-04-01), Chien et al.
patent: 5126399 (1992-06-01), Arlinghaus et al.
Goudsmit, et al, 1988, "Human Immunodeficiency Virus type 1 . . . " PNAS 85: 4478-4482.
Chemical Abstract 99:187072 (1983).
Chemical Abstract 101:204450k (1984).
Chemical Abstract 102:43238a (1985).
Chemical Abstract 96:85988h (1982).
Javaherian, et al, 1989, "Principal Neutralizing domain . . . " PNAS 86: 6768-6772.
Sandstrom, et al, 1987, "Antiviral therapy in AIDS . . . " Drugs 34: 372-390.
Martin, "Fast-Acting Slow Viruses", Nature, 345:572-573 (1990).
Smith et al., "Blocking of HIV-1 Infectivity by a Soluble Secreted Form of the CD4 Antigen", Science, 238:1704-1706.
Weber, "Blocks on the Viral Exit", Nature, 345:573-574 (1990).
Richards, "Inhibition of the Aspartic Proteinase from HIV-2", FEBS Lett. 253:214-216 (1989).
Meek et al., "Inhibition of HIV-1 Protease in Infected T-Lympho-cytes by Synthetic Peptide Analogues", Nature, 343:90-92 (1990).
Miller et al., "Antiviral Activity of Carbobenzoxy Di- and Tri-peptides on Measles Virus", Appl. Microbiol., 16:1489-1496 (1968).
Nicolaides et al., "Potential Antiviral Agents, Carbobenzoxy Di- and Tripeptides Active Against Measles and Herpes Viruses", J. Med. Chem., 11:74-79 (1968).
Finberg et al., "Prevention of HIV-1 Infection and Preservation of CD4 Function by the Binding of CPF's to gp120", Science, 249:287-291 (1990).
Erickson & Merrifield, "Solid Phase Peptide Synthesis", in: The Proteins, 3rd Ed. (1976), vol. 2, Academic Press, N.Y., Chap. 3.
Bergot et al., "Utility of Trifluoromethane Sulfonic Acid as a Cleavage Reagent in Solid Phase Peptide Synthesis", Applied Bio-systems User Bulletin, Peptide Synthesizer, Issue No. 16., Sep. 2, 1986.
Jeansson et al., "Elimination of Mycoplasmas From Cell Cultures Utilizing Hyperimmune Sera", Experimental Cell Research, 161: 181-188 (1985). Sep. 2, 1986.
"Proceedings of a Symposium on Acylovor", The Amer. Journal of Medicine, Jul. 20, 1982.
Erickson et al., "Design, Activity, and 2.8A Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease", Science, 249:527-533 (1990).
Moore et al., "In vivo Depression of Lymphocyte Traffic in Sheep by VIP and HIV (AIDS)-Related Peptides", Immunopharmacol., 16:181-189 (1988).
Rydon et al., "Polypeptides. Part IV. The Self-condensation of the Esters of Some Peptides of Glycine and Proline"; Journal of Chemical Society, Part IV; pp. 3642-3650, (1956).
Holley et al., "Prediction of optimal peptide mixtures to induce broadly neutralizing antibodies to human immunodeficiency virus type 1"; Proc. Nat'l. Acad. Sci.; vol. 88; pp. 6800-6804; (1991).
Horal Peter
Jeansson Stig
Rymo Lars
Svennerholm Bo
Vahlne Anders
Smith Lynette F.
Syntello Vaccine Development AB
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