Peptides that bind IL-2 receptors

Details Peptides that bind IL-2 receptors Peptides that bind IL-2 receptors

1994-05-27

1997-06-03

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530300, 530350, 530351, C07K 708

Patent

active

056355971

ABSTRACT:
Peptides that bind to the Interleukin-2 (IL-2) receptor subunits IL-2R.alpha., IL-2R.beta. and IL-2R.gamma., and inhibit the binding of IL-2 to these important receptors, are described. The invention also includes methods for treating diseases related to the activation of these receptors, as well as the receptors for IL-4, -7 and -13. In addition, the present invention also includes methods for assaying for the presence of these receptors on cell surfaces.

REFERENCES:
patent: 4931544 (1990-06-01), Katre et al.
patent: 5198359 (1993-03-01), Taniguchi et al.
patent: 5229109 (1993-07-01), Grimm et al.
Minami, Y. et al., "The IL-2 Receptor Complex: Its Structure, Function, and Target Genes", Annu. Rev. Immunol. 11:245-67.
Kondo, M. et al., "Sharing of the Interleukin-2 (IL-2) Receptor .gamma. Chain Between Receptors for IL-2 and IL-4", Science, 262:1874-1876 (1993).
Zurawski, G., "Analysing lymphokine-receptor interactions of IL-1 and IL-2 by recombinant-DNA technology", Tibtech, 9:250-257 (1991).
Ballard, D.W. et al., "Structure of the Human Interleukin 2 Receptor and the Biochemical Basis for its Regulation", The Molecular Aspects of Autoimmunity, pp. 219-229 (1990).
Kundig, T.M. et al., "Immune Responses in Interleukin-2-Deficient Mice", Science, 262:1059-1061, (1993).
Van Brunt, J., "Cell Therapeutics Reports on IL-2 Signaling Pathway", BioWorld Today, p. 4 (1993).
Nowak, R., "`Bubble Boy` Paradox Resolved", Science, 262:1818 (1993).
Asinari, R., "Two unsung interleukins show renewed promise", Biotechnology News, 14(4):4-6 (1994).
Noguchi, M. et al., "Interleukin-2 Receptor .gamma. Chain: A Functional Component of the Interleukin-7 Receptor", Science 262:1877-1880 (1993).
Russell, S.M. et al., "Interleukin-2 Receptor .gamma. Chain: A Functional Component of the Interleukin-4 Receptor" Science 262:1880-1883 (1993).
Bowie et al. (1990) Science. vol. 247, pp. 1306-1310.
Devlin et al. (1990) Science vol. 249. pp. 404-406.
Leonard et al. (1984) Nature vol. 311, pp. 626-631.

Affiliated with

Also associated with

Rating

Peptides that bind IL-2 receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides that bind IL-2 receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides that bind IL-2 receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-392489