Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1998-02-02
1999-10-12
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 71, 435 79, 435 791, 435 792, 435 793, 435 794, 435 795, 435975, 436518, 530326, 530327, 530826, C12Q 170
Patent
active
059653574
ABSTRACT:
A multiply-displayed peptide structure is provided for the serodiagnosis of HSV-2 antibodies, preferably by ELISA. The structure has the formula (1)): [(X.sup.1).sub.p --16aa sequence--(X.sup.2).sub.q --Sp].sub.n --core, wherein "16aa sequence" represents a sequence (SEQ ID NO: 68) Glu Glu Phe Glu Gly Ala Gly Asp Gly Glu Pro Pro 1 5 10 Glu Asp Asp Asp 15
X.sup.1 and X.sup.2 which may be the same or different represent from 1 to 6 non-interfering amino acid residues, which may be the same or different;
Sp represents a spacer group extending outwardly from the core;
n is at least 4;
p is 0 or 1;
q is 0 or 1;
and the linkage between the core and the spacer group may be chemical or physical.
Preferably p is 1, q is 1, X.sup.1 is Pro, n is 4, and the core is a branched lysine core, whereby the whole structure is a peptide. The monomeric peptides (X.sup.1).sub.p --16aa sequence--(X.sup.2).sub.q --(Sp).sub.r, where r is 0 or 1 and their functional derivatives are useful intermediates in preparing the above structures.
REFERENCES:
patent: 5229490 (1993-07-01), Tam
J-A. Liljeqvist et al., "Localization of Type-Specific Epitopes in Herpes Simplex Type 2 Glycoprotein G by Human Antibodies", 22.sup.nd Herpesvirus Workshop, University of California, La Jolla, San Diego, Aug. 2-8 1997, Abstract N.sup..degree. 125.
J-A. Liljeqvist et al., "Definition of an Antigenic Site of Herpes Simplex Type 2 Glycoprotein G by Monoclonal Antibodies", 21.sup.st Herpesvirus Workshop, Northern Illinois University, Chicago, Jul. 27-Aug. 2, 1996, Abstract N.sup..degree. 431.
J-A. Liljeqvist et al., "Definition of an Antigenic Site of Herpes Simplex Type 2 Glycoprotein G by Monoclonal Antibodies", 21.sup.st Herpesvirus Workshop, Northern Illinois University, Chicago, Jul. 27-Aug. 2, 1996, Photographs taken of a displayed poster.
A. Grabowskwa et al., "Identification of type-specific epitopes of the glycoprotein G of HSV-2 using a phage peptide display library", 21 .sup.st Herpesvirus Workshop, Northern Illinois University, Chicago, Jul. 27-Aug. 2, 1996, Abstract N.sup..degree. 136.
A. Grabowskwa et al., "Identification of type-specific epitopes of the glycoprotein G of HSV-2 using a phage peptide display library", 21.sup.st Herpesvirus Workshop, Northern Illinois University, Chicago, Jul. 27-Aug. 2, 1996, Photographs taken of a displayed poster.
M. Levi et al., Peptide Sequences of Glycoprotein G-2 Discriminate between Herpes Simplex Virus Type 2 (HSV-2) and HSV-1 Antibodies, Clinical and Diagnostic Laboratory Immunology, 3, 265-269 (1996).
J. P. Tam, "Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system", Proc. Natl. Acad. Sci. USA, 85, 5409-5413 (1988).
H. S. Marsden et al., "Physical Mapping of Herpes Simplex Virus-Induced Polypeptides", J. Virology 28, 624-642 (1978).
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M. C. Frame et al., "Novel Herpes Simplex Virus Type 1 Glycoproteins Identified by Antiserum against a Synthetic Oligopeptide from the Predicted Product of Gene US4", J. gen. Virol. 67, 745-751 (1986).
M. Ackermann et al., "Identification, Properties, and Gene Location of a Novel Glycoprotein Specified by Herpes Simplex Virus 1 ", Virology 150, 207-220 (1986).
D. J. McGeoch et al., "DNA Sequence and Genetic Content of HindIII l Region in the Short Unique Component of the Herpes Simplex Virus Type 2 Genome: Identification of the Gene Encoding Glycoprotein G, and Evolutionary Comparisons", J. gen. Virol. 68, 19-38 (1987).
World Health Organisation, Regional Office for Europe, "Epidemiology of Herpes Simplex Virus Infections and Surveillance of other STDs in Europe", Report on a Workshop, Copenhagen 19-20 Jun. 1995.
Liljeqvist et al., "Localization of type-specific epitodes of herpes simplex . . . ," Journal of General Virology, vol. 79, pp. 1215-1224 (1998).
Medical Research Council
Stucker Jeffrey
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