Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-12-30
1999-03-30
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 536 231, C12P 2106, C12N 120, C07H 2100
Patent
active
058887636
ABSTRACT:
The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.
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Cowburn David
Feller Stephan M.
Hanafusa Hidesaburo
Knudsen Beatrice S.
Kuriyan John
Mytelka Daniel S.
The Rockefeller University
Wax Robert A.
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