Peptides representing epitopic sites for the major HTLV-I envelo

Details Peptides representing epitopic sites for the major HTLV-I envelo Peptides representing epitopic sites for the major HTLV-I envelo

1988-05-25

1991-03-26

Doll, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, C07K 710, C07K 700

Patent

active

050030434

ABSTRACT:
The present invention discloses synthetic peptides and antibodies raised thereto wherein the synthetic peptides represent important epitopic sites recognized by the 0.5 .alpha. antibody, a human monoclonal antibody which can neutralize HTLV-I. Also, the uses of these peptides or antibodies thereto either alone or in combination with peptides representing the epitopic site for the predominant antibodies found in HTLV-I env seropositive sera as diagnostics, therapeutics and vaccines are disclosed.

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T. D. Copeland, "Envelope Proteins of Human T Cell Leukemia Virus Type I: Characterization by Antisera to Synthesize Peptides and Identification of a Natural Epitope, " J. of Immunology 137(9): 2945-2951 (1986).
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E. S. Kleinerman et al., "A Synthetic Peptide Homologous to the Envelope Proteins of Retroviruses Inhibits Monocyte-Mediated Killing by Inactivating Interleukin 1", J. of Immunology 139(7): 239-2337 (1987).
H. Nakamura, "Protection of Cynomolgus Monkeys Against Infection by Human T-Cell Leukemia Virus Type-I by Immunization with Viral Env Gene Products Produced in Escherichia coli", Int. J. Cancer 40: 403-407 (1987).
T. J. Palker et al., "Mapping of Immunogenic Regions of Human T-Cell Leukemia Virus Type I (HTLV-I) gp46 and gp21 Envelope Glycoproteins with Env-Encoded Synthetic Peptides and a Monoclonal Antibody to gp46", J. of Immunology 142(3): 971-978 (1989).

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