Peptides relating to the extracellular membrane-bound segment of

Details Peptides relating to the extracellular membrane-bound segment of Peptides relating to the extracellular membrane-bound segment of

1996-03-20

1997-11-25

Scheiner, Laurie A.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241841, 4241301, 4242781, 436513, 5303871, 5303873, 5303881, 5303891, 5303915, A61K 39395

Patent

active

056909349

ABSTRACT:
The invention relates to unique extracellular peptide segments present on B cell-bound but not secreted IgA. These extracellular peptide segments form, entirely or in part, antigenic epitopes unique to membrane-bound but not secreted IgA, and thereby provide a unique epitope on the IgA-bearing B cells to which membrane-bound IgA is attached. These peptide segments can be used as immunogens to generate antibodies which specifically target membrane-bound IgA and IgA-bearing B cells.

REFERENCES:
Sitia et al., "Membrane-Bound and Secreted IgA Contain Structurally Different .alpha.-Chains", J. Immunol. 128(2):712-716, Feb. 1982.
Cushley et al., Nature 298:577-79 (1982).
Burnett et al., EMBO J. 8:4041-47 (1989).
Robinson et al. PNAS 11:4909-13 (1980).
Osborne et al. 119:925-32 (1988).
Loghem et al. vol. 20 (1983).
Blattner et al. 307:417-22 (1984).

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