Peptides of the formula (KFmoc) ZZZ and their uses

Details Peptides of the formula (KFmoc) ZZZ and their uses Peptides of the formula (KFmoc) ZZZ and their uses

1993-06-18

1995-08-08

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530345, A61K 3807

Patent

active

054400163

ABSTRACT:
Peptides having Anti-microbial activity and having the formula (KFmoc)ZZZ-NH.sub.2, wherein Z is an amino acid are disclosed. Also disclosed are peptides having anti-trypsin activity and having the formula Ac-rypwz-NH.sub.2, wherein z is a D-amino acid. Also disclosed are compositions containing these peptides and methods of using them.

REFERENCES:
patent: 4369137 (1983-01-01), Hearner
patent: 4613586 (1986-09-01), Barchas
patent: 4631211 (1986-12-01), Houghten
Pinilla, Clemencia et al., "Rapid Identification of High Affinity Peptide Ligands Using Positional Scanning Synthetic Peptide Combinatorial Libraries." Biotech. 13:901-905 (1992).
Houghten, R. A. et al., "The Use of Synthetic Peptide Combinatorial Libraries for the Identification of Bioactive Peptides." Biotech. 13:412-421 (1992).
Tam, James P. et al., "S.sub.N 2 Deprotection of Synthetic Peptides with a Low Concentration of HF in Dimethyl Sulfide: Evidence and Application in Peptide Synthesis." J. Am. Chem. Soc. 105:6442-6455 (1983).
Gisin, B. F. "The Monitoring of Reactions in Solid-Phase Peptide Synthesis with Picric Acid." Analytica Chimica Acta. 58:248-249 (1972).
Houghten, Richard A. et al., "Simplified Procedure for Carrying out Simultaneous Multiple Hydrogen Fluoride Cleavages of Protected Peptide Resins." J. Peptide Protein Res. 27:673-678 (1986).
Houghten, Richard A. et al., "Generation and Use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Discovery." Nature 354:84-86 (1991).
Blondelle, Sylvie E. et al., "Hemolytic and Antimicrobial Activities of the Twenty-Four Individual Omission Analogues of Melittin." Biochem. 30:4671-4678 (1991).
Houghten, Richard A. "General Method for the Rapid Solid-Phase Synthesis of Large Numbers Of Peptides: Specificity of Antigen-Antibody Interaction at the Level of Individual Amino Acids." Proc. Natl. Acad. Sci. USA. 82:5131-5135 (1985).
Dooley, Colette T. and Houghten, Richard A. "The Use of Positional Scanning Synthetic Peptide Combinatorial Libraries for the Rapid Determination of Opioid Receptor Ligands." Life Sciences. 52:1509-1517 (1993).
Blondelle, Sylvie E. and Houghten, Richard A. "Probing the Relationships Between the Structure and Hemolytic Activity of Melittin with a Complete Set of Leucine Substitution Analogs." Peptide Research. 4(1):12-18 (1991).
Cuervo, Julio H. et al. "The Magainins: Sequence Factors Relevant to Increased Antimicrobial Activity and Decreased Hemolytic Activity." Peptide Research. 1(2):81-86 (1988).
Cuervo et al., Synthesis and antimicrobial activity of magainin alanine substitution analogs. In: "Peptides, Proceedings of the 11th American Peptide Symposium" (J. E. Rivier and G. Marshall, Eds.). Escom Science Publishers B.V., The Netherlands 1240126 (1990).
Blondelle et al., The effect of induced conformation on antimicrobial and hemolytic activity of amphipathic peptides. In: "Peptides 1990: Proceedings of the 21st European Peptide Symposium" (E. Giralt and D. Andreu, Eds.) ESCOM Science Publishers B.V., 738-739 (1991).
Blondelle and Houghten, "Design of model amphipathic peptides having potent antimicrobial activities" Biochemistry 31:12688-12694 (1992).
Houghten et al., The use of a peptide library composed of 34, 012,224 hexamers for basic research and drug discovery. In: "Peptides: Chemistry and Biology, Proceedings of the 12th American Peptide Symposium" (J. A. Smith and J. E. Rivier, Eds.) ESCOM, Leiden 560-561 (1992).
Houghten et al., "The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides" Biotechniques 13(3):412-421 (1992).
Houghten et al., Development of new antimicrobial agents using a synthetic peptide combinatorial library involving more than 34 million hexamers. In: "Innovation and Perspectives in Solid Phase Synthesis: Peptides, Polypeptides and Oligonucleotides" (R. Epton, Ed.) Intercept Limited, Andover, 237-239 (1992).
Blondelle et al., The relationship between potential induced conformation of melittin and its hemolytic activity. In "Peptides: Chemistry and Biology, Proceedings of the 12th American Peptide Symposium" (J. A. Smith and J. E. Rivier, Eds.) ESCOM, Leiden, 433-434 (1992).
Blondelle and Houghten, Role of individual amino acid residues on melittin's haemolytic activity. In: "Innovation and Perspectives in Solid Phase Synthesis: Peptides, Polypeptides and Oligonucleotides" (R. Epton, Ed.) Intercept Limited, Andover, 121-127 (1992).
Blondelle et al., Inhibition of melittin's hemolytic activity using synthetic peptide combinatorial libraries. In: "Peptides 1992: Proceedings of the 22nd European Peptide Symposium" (C. H. Schneider & A. N. Eberle, Eds.) ESCOM, Leiden, 761-762 (1993).
Houghten et al., "The systematic development of peptides having potent antimicrobial activity against E. coli through the use of synthetic peptide combinatorial libraries." Techniques In Protein Chemistry IV, 249-256 (1993).
Eichler and Houghten, "Preparation of synthetic peptide combinatorial libraries on cotton carriers and their application to the identification of trypsin inhibitors." Peptides, 320-321 (1992).
Bodansky Principles of Peptide Synthesis, pp. 125-126 1984.

Affiliated with

Also associated with

Rating

Peptides of the formula (KFmoc) ZZZ and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides of the formula (KFmoc) ZZZ and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides of the formula (KFmoc) ZZZ and their uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-972260