Peptides of the AT 1 receptor and their uses

Details Peptides of the AT 1 receptor and their uses Peptides of the AT 1 receptor and their uses

1999-12-22

2010-06-29

Saoud, Christine J (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S300000, C530S388220

Reexamination Certificate

active

07745139

ABSTRACT:
Disclosed are peptides of the AT1receptor and their use for eliminating specifically binding, cell-physiologically active, pathological antibodies in preeclampsia and malign hypertension. The peptides may, for example, be used for the diagnosis of preeclampsia. Peptides having the sequence AFHYESQ (SEQ ID NO: 1), AVHYQSN (SEQ ID NO: 2), SHFYQTR (SEQ ID NO: 3), GYYFDTN (SEQ ID NO: 4) or ENTNIT (SEQ ID NO: 5) are preferred.

REFERENCES:
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Fu Michael LX et al.:“localization of angiotensin II receptors (ATI) in the heart with anti-peptide antibodies showing a positive chronotropic effect”, abstract No. 232600, Chemical Abstracts, Columbus, Ohio, US, vol. 130, No. 18. May 3, 1999 & Recept. channels, 6(2), 99-111, 1998, XP002140152.
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