Peptides of the antigen Sm-D and their use, in particular for th

Details Peptides of the antigen Sm-D and their use, in particular for th Peptides of the antigen Sm-D and their use, in particular for th

1996-10-18

1999-08-31

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

514 12, 530324, A61K 3800

Patent

active

059451050

ABSTRACT:
Peptides of the antigen Sm-D and their use, in particular for the diagnostics of the SLE. The invention relates to peptides of the antigen Sm-D, comprised of 35 to 45 amino acids, which form a conformation epitope and which are capable of binding autoantibodies, such as they occur in connection with systemic lupus erythematosus (SLE). Particularly preferred is the peptide of 37 amino acids with the structure VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR (SEQ ID NO:3) and its mutants and variants, respectively.

REFERENCES:
patent: 5407833 (1995-04-01), Van Regenmortel
Wraith et al., Cell, vol. 59: 247-255, Dec. 1989.
Tisch et al., Proc. Natl. Acad. Sci. USA, vol. 91: 437-438, Jan. 1994.

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