Peptides of human immunodeficiency virus type 2 (HIV-2) and in v

Details Peptides of human immunodeficiency virus type 2 (HIV-2) and in v Peptides of human immunodeficiency virus type 2 (HIV-2) and in v

1994-03-17

1996-12-03

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4241881, 4242081, 435 691, 4351723, 435974, 435 5, 536 2372, G01N 3353, G01N 33564, A61K 3521, G12P 2106

Patent

active

055807399

ABSTRACT:
A novel lentivirus, designated the human immunodeficiency virus type 2 (HIV-2.sub.ROD), was isolated from West African patients with acquired immune deficiency syndrome (AIDS). A recombinant lambda phage library was constructed from HIV-2.sub.ROD -infected CEM genomic DNA. Overlapping molecular clones were obtained and the nucleotide sequence of the complete 9.5-kilobase (kb) HIV-2.sub.ROD genome ascertained. The genetic organization of HIV-2 is analogous to that of other retroviruses and consists of the 5'LTR-gag-pol-central region-env-nef-3'LTR. The central region also encodes for the regulatory proteins Tat and Rev, as well as the ancillary proteins Vif, Vpr, and Vpx. The proteins encoded by this proviral clone will provide novel immunologic, biochemic, and diagnostic reagents useful for the detection of HIV-2.

REFERENCES:
patent: 4629783 (1986-12-01), Cosand
patent: 4839288 (1989-06-01), Montagnier et al.
patent: 5079342 (1992-01-01), Alizon et al.
Gallo et al., "HIV/HTLV gene nomenclature", Nature 333:564 (1988).
Laurence, J., "Summary of HIV-1 and HIV-2 nomeclature", AIDS Res. Hum. Retro. 4:vii-viii (1988).
(a) Clavel et al., "Molecular cloning and polymorphism of the human immunodeficiency virus type 2", Nature 324:691-695 (1986).
Clavel et al., "Isolation of a new Human Retrovirus from West African Patients with AIDS," Science, 233, pp. 343-346 (1986).
Allan et al., "Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III," Sceience, 228, pp. 1091-1094 (1985).
Chang et al., "Detection of Antibodies to Human T-Cell Lymphotropic Virus-III (HTLV-III) with an Immunoassay Employing a Recombinant Escherichia coli-Derived Viral Antigenic Peptide," Bio/Technology, 3, pp. 905-909 (1985).
Kanki et al., "Isolation of T-lymphotropic Retrovirus Related to HTLV-III/LAV from Wild-Caught African Green Monkeys," Science, 230, pp. 951-954 (1985).
Kanki et al., "Serologic Identification and Characterization of a Macaque T-lymphotropic Retrovirus Closely Related to HTLV-III," Science, 228, pp. 1199-1201 (1985).
Clavel et al., "LAV TypeII: A Second Retrovirus Associated With AIDS in West Africa," C. R. Acad. Sc. Paris, Serie III, 302, pp. 485-488 (1986).
Klatzmann et al., "T-lymphocyte T4 Molecule Behaves As The Receptor For Human Retrovirus LAV, " Nature, 312, pp. 767-768 (1984).
Daniel et al., "Isolation of T-Cell Tropic HTLV-III-like Retrovirus from Macaques," Science, 228, pp. 1201-1204 (1985).
Barin et al., "Serological Evidence For Virus Related To Simian T-lymphotropic Retrovirus III in Residents of West Africa," The Lancet, pp. 1387-1389 (Dec. 21/28, 1985).
Sandstrom et al., "Antiviral Therapy in AIDS Clinical Pharmacological Properties and Therapeutic Experience to Date," Drugs, 34, pp. 372-390 (1987).
Mitsuya et al., "Protection of T Cells Against Infectivity and Cytopathic Effect of HTLV-III In Vitro," Retroviruses in Human Lymphoma/Leukemia, M. Miwa et al., eds., pp. 277-288 (Japan Science Press, Tokyo, 1985).

Affiliated with

Also associated with

Rating

Peptides of human immunodeficiency virus type 2 (HIV-2) and in v does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides of human immunodeficiency virus type 2 (HIV-2) and in v, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides of human immunodeficiency virus type 2 (HIV-2) and in v will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-784513