Peptides modified by the phosphine group for marking with 99M TC

Details Peptides modified by the phosphine group for marking with 99M TC Peptides modified by the phosphine group for marking with 99M TC

1995-06-23

1997-06-03

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 145, 424 165, 424 177, 424 934, 424 936, 424 9365, 534 10, 534 11, 534 14, 534 16, 534300, 534311, 534323, 568 8, 568 10, 568 17, 564161, 562 8, A61K 5108, A61K 3800, C07F 902, A61B 5055

Patent

active

056351585

ABSTRACT:
The peptides described are modified with the phosphine group and are useful for marking with .sup.99m Tc and .sup.186-188 Re or paramagnetic agents for use in diagnosis and radiotherapy; in particular chelating compounds having the co-ordinating sets PN.sub.2 X, where X is --S, --O, COO--, PN.sub.3, P.sub.2 N.sub.3 and P.sub.2 N.sub.2 are described.

REFERENCES:
patent: 5382654 (1995-01-01), Lyle et al.
Santimaria et al., "Preparation and Characterization of a new rhenium(v) complex containing the 3-diphenylphosphinopropinoylglycyl-L-(S-benzl)-cysteinyl methyl ester ligand", Inorganica Chimica Acta, 240, pp. 291-297, 1995.
"Synthesis and Characterization of Technetium and Rhenium Complexes of N,N'-1,2-ethylenediylbis-L-cysteine. Neurolite.RTM. and Its Metabolites", pp. 433-444 (Conference Technetium and Rhenium In Chemistry and Nuclear Medicine 3, Cortina International 1989).
"Synthesis and Characterization of Neutral Technetium (III)-99 and -99m Complexes with O,P-Bidentate Phosphinocarboxylate Ligands. Crystal Structure of mer-[Tc(02CCH2CH2PPh2)3]. 2Me2SO+", (J. Chem. Soc. Dalton Tras., vol. 19, pp. 2901-2908, 1993).
"Neutral Technetium (II)-99m Complexes As Potential Brain Perfusion Imaging Agents", (Nucl. Med. Biol., vol. 14, Nos. 5, 1987, pp. 503-510).

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