Peptides method for radiolabeling them, and method for detecting

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 169, 530300, 530330, 530331, A61K 4900, G01N 3100, G01N 3348

Patent

active

056701330

ABSTRACT:
High affinity chemotactic peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of infections, inflammations and related conditions.

REFERENCES:
patent: 4424200 (1984-01-01), Crockford et al.
patent: 4427646 (1984-01-01), Olexa et al.
patent: 4427660 (1984-01-01), Schiffman et al.
patent: 4732864 (1988-03-01), Tolman
patent: 4877868 (1989-10-01), Reno et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5089249 (1992-02-01), Fritzberg et al.
patent: 5091514 (1992-02-01), Fritzberg et al.
patent: 5102990 (1992-04-01), Rhodes
patent: 5128119 (1992-07-01), Griffiths
patent: 5162505 (1992-11-01), Dean
patent: 5169933 (1992-12-01), Anderson et al.
patent: 5225180 (1993-07-01), Dean et al.
patent: 5277892 (1994-01-01), Rhodes
patent: 5371184 (1994-12-01), Rajagopalan et al.
patent: 5443815 (1995-08-01), Dean et al.
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5508020 (1996-04-01), Dean et al.
Cox, et al., "Technetium Labelled Somatostatin a Potential Agent for in Vivo Tumour Localization," 7th Intn'l Sympos. on Radiopharmacology, Abstract, p. 16 (1991).
Fischman, Alan J., "A Ticket to Ride: Peptide Radiopharmaceuticals," J. Nucl. Med., vol. 34, No. 12 pp. 2253-2263, (Dec. 1993).
Knaw, B.A., et al., "Technetium-99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibrigen," J. of Nucl. Med., Basic Sciences, vol. 23, No. 11, pp. 1011-1019 (1982).
Kondo, M., et al., "Studies of Dimeric fMLF with High Chemotactic Activities," Peptides --Chemistry and Biology, Proc. of 12th Amer. Peptide Symp., Cambridge MA (Jun. 16-21, 1991).
Pimm MV, et al: In Labeling of A Branched Polypeptide Drug-Carrier With A Poly(L-lysine) Backbone. Int'l J. Pharm. 79:77-80, 1992.
Fischman, A.J., et al., "Imaging Focal Sites of Bacterial Infection in Rats with Indium-111-Labeled Chemotactic Peptide Analogs," J. Nuclear Medicine,vol. 32, No. 3, pp. 483-491 (1991).
Fischman, A.J., et al., Abstract, "Imaging of Focal Sites of Inflammation in Non-Human Primates with a TC99m-Labeled Chemotactic Peptide," Proc. of 40th Ann. Meeting. Journal of Nuclear Medicine, Abstract No. 415 (1992).
Vallabhaiosula, S., et al., "Evaluation of Technetium-99m Labeled Peptides for Imaging Infection in a Rabbit Model," Proc. of 40th Ann. Meeting, Journal of Nuclear Medicine, vol. 34, No. 5, Abstract No. 414 (1993).
Babich, J.W., et al., "Technetium-99m-Labeled Chemotactic Peptides for Infection Imaging: Comparison with Indium-111-labeled Leukocytes in Infected Rabbits," Proc. 40th Ann. Meeting, Journal of Nuclear Medicine, vol. 34, No. 5, Abstract 833 (1993).
Babich, J.W., et al., "Tc99m-Labeled Hydrazino Nicotinamide Derivatized Chemotactic Peptide Analogs for Imaging Focl Sites of Bacterial Infection in Rabbits," Proc. 40th Ann. Meeting, Journal of Nuclear Medicine, vol. 34, No. 5, Abstract 836 (1993).
Kraus, J, et al., "Cyclic Tetrameric Clusters of Chemotactic Peptides as Superactive Activators of Lysozyme, Release from Human Meutrophils," BioChem. and BioPhy. Res. Comm., vol. 124, No. 3 pp. 939-944 (1994).
Ravel, P., "Polymeric Analogues of N-formyl Peptides are Potent Activators of Degranulation and Superoxide Production by Human Neutrophils," Biochem. and Biophy. Res. Comm., vol. 171, No. 1, p. 266-272 (1980).
Pearson et al (1996), J. Medicinal Chemistry, vol. 39, No. 7, pp. 1372-1382, "Thrombus Imaging Using Technetium-99m Labeled High Potency GPIIB/IIIA Receptor Antagonists. Chemistry and Initial Biological Studies".
Babich et al (1993). The Journal of Nuclear Medicine, vol. 34, No. 11, pp. 1964-1974. "Technetium-99m Labeled Hydrazino Nicotinamide Derived Chemotactic Peptide Analogs for Imaging Focal Sites of Bacterial Infection".
Babich et al (1993). The Journal of Nuclear Medicine, vol. 34, No. 12, pp. 2176-2181 "Technetium-99m Labeled Chemotactic Peptides: Comparison with Indium-111 Labeled White Blood Cells for Localizing Acute Bacterial Infection in the Rabbit".

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Peptides method for radiolabeling them, and method for detecting does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides method for radiolabeling them, and method for detecting, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides method for radiolabeling them, and method for detecting will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1937814

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.