Peptides ketoamides

Details Peptides ketoamides Peptides ketoamides

1995-10-06

1997-03-11

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

548496, 548535, 5483127, 5483147, 548953, 560 32, 560 38, 560 40, 560 41, 560 45, 560125, 560159, 560169, 564153, 564157, 564159, 546210, 546207, 546201, 5462681, 5462727, 5462774, 5462791, C07D26530

Patent

active

056102976

ABSTRACT:
A novel class of peptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M.sub.1 -AA-NH--CHR.sub.2 --CO--CO--NR.sub.3 R.sub.4, M.sub.1 -AA.sub.2 -AA.sub.1 -CO--NR.sub.3 R.sub.4, M.sub.1 -AA-AA-AA-CO--NR.sub.3 R.sub.4, M.sub.1 -AA-AA-AA-AA-CO--NR.sub.3 R.sub.4, or M.sub.1 -AA-CO--NR.sub.3 R.sub.4.

REFERENCES:
patent: 5514694 (1996-05-01), Powers
Hu, Arch. Biochem. Biophys., 281, pp. 271-274 (received in PTO Sep. 10, 1990).
Burkhart, Tetrahedron Lett., 29, pp. 3433-3436 (1988).

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