Peptides involved in the pathogenesis of HIV infection

Details Peptides involved in the pathogenesis of HIV infection Peptides involved in the pathogenesis of HIV infection

1988-08-16

1990-07-24

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, C07K 708, C07K 710

Patent

active

049436279

ABSTRACT:
This invention relates to peptides involved in the pathogenesis of human immunodeficiency virus ("HIV"). More particularly, this invention relates to peptides from the env region of the HIV genome and the use of such peptides in methods and compositions for preventing, treating, or detecting acquired immune deficiency syndrome ("AIDS") infection.

REFERENCES:
patent: 4520113 (1985-05-01), Gallo et al.
patent: 4629783 (1986-12-01), Cosand
patent: 4663436 (1987-05-01), Elder et al.
Starcich et al, Cell, vol. 45, pp. 637-648, (6/6/1986).
Kennedy et al, Science, vol. 231, pp. 1556-1559, (3/28/1986).
N. T. Chang et al., "An HTLV-III Peptide Produced by Recombinant DNA is Immunoreactive with Sera from Patients with AIDS", Nature, 315, pp. 151-154, (5/1985), [Change et al. I].
N. T. Chang et al., "Expression in Escherichia coli of Open Reading Frame Gene Segments of HTLV-III", Science, 228, pp. 93-96, (4/1985), [Chang et al. II].
T. W. Chang et al., "Detection of Antibodies to Human T-Cell Lymphotropic Virus-III (HTLV-III) with an Immunoassay employing a Recombinant Escherichia coli-Derived Viral Antigenic Peptide", Biotechnology, 3, pp. 905-909, (Oct. 1985).
R. Crowl et al., "HTLV-III env Gene Products Synthesized in E. coli are recognized by Antibodies present in the Sera of AIDS Patients", Cell, 41, pp. 979-986, (Jul. 1985).
D. Pauletti et al., "Application of a Modified Computer Algorithm in Determining Potential Antigenic Determinants Associated with the AIDS Virus Glycoprotein", Analytical Biochemistry, 151, pp. 540-546, (received for publication Jul. 1, 1985).
L. Ratner et al., "Complete Nucleotide Sequence of the AIDS Virus, HTLV-III", Nature, 313, pp. 277-284, (Jan. 1985).

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