Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Reexamination Certificate
2003-12-12
2010-06-01
Lukton, David (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C514S002600, C530S328000, C530S325000
Reexamination Certificate
active
07728105
ABSTRACT:
The present invention relates to peptides which impair PBX-dependent regulation of gene transcription. In particular, the invention provides the use of a peptide comprising the amino acid sequence X1X2X3W M X4X5X6X7, wherein the sequence X1to X7is an amino acid sequence comprising at least 9 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein;X1is selected from W, T, PE, KQI, VV, PQT, H, RI and absent;X2is an amino acid with an aromatic side chain;X3is P or D;X4is an amino acid with a basic side chain;X5is an amino acid with a charged side chain;X6is an amino acid with a charged side chain; andX7is an amino acid with a basic side chain or Serine;in the manufacture of a medicament for treating or preventing a disorder in which aberrant cell division occurs.
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Forraz Nicolas Pierre Benoît
McGuckin Colin Patrick
Morgan Richard George Leonard
Pettengell Ruth
Fulbright & Jaworski L.L.P.
Lukton David
St. George's Hospital Medical School
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