Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Reexamination Certificate
2003-01-18
2010-02-16
Kosar, Andrew D (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
C530S333000, C530S334000, C530S339000
Reexamination Certificate
active
07662915
ABSTRACT:
The present invention relates to synthetic peptides having selectively protected amines of untargeted sites and to methods for production thereof and for specifically conjugating PEG to targeted sites of the synthetic peptides using the same. The present invention provides a much higher yield of PEG conjugated peptides in which PEG is specifically combined to amines at targeted sites.
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Lee et al., “Site-specific PEGylated Peptide Drugs for Enhanced Therapeutic Efficacy,” Presentation, Controlled Release Society 29th Annual Meeting Proceedings, Jul. 20-25, 2002, 2 pps.
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Lee Kang Choon
Lee Sang Deuk
Na Dong Hee
Youn Yu Seok
Heslin Rothenberg Farley & & Mesiti P.C.
Kosar Andrew D
Pegsphere Co., Ltd.
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