Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-08-07
1999-10-26
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, A61K 3800
Patent
active
059728949
ABSTRACT:
This invention concerns methods for prophylactic and therapeutic treatment of diseases responsive to the opening of potassium channels, peptides having potassium channel opener activities, and pharmaceutical compositions and kits comprising such peptides.
REFERENCES:
patent: 4057636 (1977-11-01), Petersen
patent: 4200640 (1980-04-01), Nagano et al.
Friedel, Heather A., et al., "Pinacidil, A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in the Treatment of Hypertension," Drugs, vol. 39, (6) 1990, pp. 929-967.
Grover, Gary J., et al., "Cardioprotective Effects of the Potassium Channel Opener Cromakalim: Stereoselectivity and Effects on Myocardial Adenine Nucleotides," J. Pharmac. & Expt'l. Therapeutics, 257(1):156-162, 1991.
Lipton, Howard L., et al., "Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation," J. Appl. Physiol. 70(2):947-952, 1991.
Lynch, Jr., Joseph J., et al., "Therapeutic potential of modulating potassium currents in the diseased myocardium," Symposium "Therapeutic Potential of Modulating Potassium Currents in the Diseased Myocardium", Apr. 25, 1991.
Meisheri, Kaushik D., et al., "A Sensitive In Vitro Functional Assay to Detect K.sup.+ -Channel-Dependent Vasodilators," J. Pharmac. Methods, 24, 251-261 (1990).
Remington, Julianne, "Potassium Channel Implicated in Wide Array of Diseases," Press Release for Oregon Health Sciences University, (1996) http://www.orst.edu/Dept . . . nnect/con71/adelman.html.
Abele April et al., "Potassium Channel Activators Abolish Excitoxicity in Cultured Hippocampal Pyramidal Neurons," Neuroscience Letters, vol. 115, pp. 195-200, (1990).
Almquist R. G. et al., "Synthesis and Biological Activity of a Ketomethylene Analogue of a Tripeptide Inhibitor of Angiotensin Converting Enzyme" J. Med. Chem., vol. 23, pp. 1392-1398, (1980).
Archives of Biochemistry and Biophysics, IUPAC-IUB Combined Commission on Biochemical Nomenclature; Abbreviations and Symbols for Chemical Names of Special Interest in Biological Chemistry; Revised Tentative Rules (1965), recommandations, vol. 115, pp. 1-12, (1966).
Ashford et al., Cloning and Functional Expression of a Rat Heart K.sub.ATP Channel, Nature, vol. 370, pp. 456-459, (Aug. 11, 1994).
Babenko A. P. et al., "Activation of ATP-Sensitive K+ Channels of Cardiomyocytes by Endogenous Cardiopeptides," Bull. Eksp. Biol. Med., Russia, vol. 114, No. 7, pp. 54-56, (1992).
Ben-Ari et al., "Activators of ATP-Sensitive K+ Channels Reduce Anoxic Depolarization in CA3 Hippocampal Neurons," Neuroscience, vol. 37, pp. 55-60, (1990).
Carmeliet E., "Ion Channel Agonists: Expectations for Therapy," Eur. Heart J., vol. 12, Supplement F, pp. 30-37, (1991).
Cook Nigel et al., "Anti-Vasoconstrictor Effects of the K.sup.+ Channel Opener Cromakalim on the Rabbit Aorta-Comparison With The Calcium Antagonist Isradipine," Br. J. Pharmacologie, vol. 95, pp. 741-752, (1988).
Dilly S. G., "Cromakalim/Lemakalim, Experience in Hypertension and Nocturnal Asthma," Conference Documentation, Potassium Channels '90, The Royal College of Physicians, Dec. 6-7, 1990, 17 pages.
Downing S. J. et al., "Interaction Between Myometrial Relaxants and Oxytocin: a Comparison Between Relaxin, Cromakalim and Salbutamol," J. Endocrinol., vol. 135, p. 29, (1992).
Evans B. E. et al., "Design of Nonpeptidal Ligands for a Peptide Receptor: Cholecystokinin Antagonists," J. Med. Chem., vol. 30, pp. 1229-1239, (1987).
Escande et al., "K+ Channel Openers and `Natural` Cardioprotection," Trends in Pharm. Sci., vol. 23, pp. 269-272, (1992).
Fauchere, Jean-Luc, "Elements for the Rational Design of Peptide Drugs," Adv. Drug. Res., vol. 15, pp. 29-69, (1986).
Gandolfo et al., "K+Channel Openers Decrease Seizures in Genetically Epiletic Rats," Europ. J. Pharmac., vol. 167, pp. 181-183, (1989).
Gopalakrishnan Murali et al., "ATP-Sensitive K+ Channels: Pharmacologic Properties, Regulation, and Therapeutic Potential," in Drug Dev. Res., vol. 28, pp. 95-127, (1993).
Grover Gary J. et al., "Anti-Ischemic Effects of the Potassium Channel Activators Pinacidil and Chromakalim and the Reversal of these Effects With the Potassium Channel Blocker Glyburide," J. Pharmac. & Expt'l Therapeutics, vol. 251, No. 1, pp. 98-104, (1989).
Grover Gary J. et al., "Reduction of Ischemic Damage in Isolated Rat Hearts by the Potassium Channel Opener, RP 52891," Europ. J. Pharmac., vol. 191, pp. 11-18, (1990).
Grover Gary J. et al., "Cardioprotective Effects of the Potassium Channel Opener Cromakalim: Stereoselectivity and Effects on Myocardial Adenine Nucleotides," J. Pharmac. & Expt'l Therapeutics, vol. 257, No. 1, pp. 156-162, (1991).
Guermonprez J. L. et al., "A Double-Blind Comparison of the Long-Term Efficacity of a Potassium Channel Opener and a Calcium Antagonist in Stable Angina Pectoris," Eur. Heart J., vol. 14, Supplement B, pp. 30-34, (1993).
Hann Michael M. et al., "On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue," J. Chem. Soc. Perkin Trans., pp. 307-314, (1982).
Holladay M. W. et al., "Synthesis of Hydroxyethylene and Ketomethylene Dipeptide Isosteres," Tetrahedron Lett., vol. 24, pp. 4401-4404, (1983).
Hudson, D. et al., "Methionine Enkephalin and Isosteric Analogues," Int. J. Pept. Prot. Res., vol. 14, pp. 177-185, (1979).
Hruby V. J., "Conformational Restrictions of Biologically Active Peptides Via Amino Acid Side Chain Groups," Life Science, vol. 31, pp. 189-199, (1982).
Jennings-White Clive et al., "Synthesis of Ketomethylene Analogs of Dipeptides," Tetrahedron Lett., vol. 23, No. 25, pp. 2533-2534, (1982).
Khlystov, V.V. et al., "Ultrastructure of the Periinfarction Zone in Experimental Myocardial Innfarction Treated With Cardiolin," Archive Pathology, (USSR) vol. 9, pp. 27-31, (1989).
Kidney et al., "Effect of an Oral Potassium Channel Activator, BRL 38227, on Airway Function and Responsiveness in Asthmatic Patients: Comparison With Oral Salbutamol," Thorax, vol. 48, pp. 130-133, (1993).
McPherson Grant A., "Current Trends in the Study of Potassium Channel Openers," Gen. Pharmac. vol. 24, No. 2, pp. 275-281, (1993).
Merrifield R. B., "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide," J. Am. Chem. Soc., vol. 85, pp. 2149-2154, (1963).
Morley, J. S., "Modulation of the Action of Regulatory Peptides by Structural Modification," Trends Pharm Sci., pp. 463-468, (Dec. 1980).
Nielsen-Kudsk Jens Erik et al., "Effects of Pinacidil on Guinea-Pig Airway Smooth Muscle Contracted by Asthma Mediators," Europ. J. Pharmac., vol. 157, pp. 221-226, (1988).
Pavlenko V. S. et al., "Effect of a Polypeptide Preparation on the State of Myocardial Cell Energy Metabolism During Hypoxia and Ischemia," Bull. Eksp. Biol. Med., (USSR), vol. 112, No. 7, pp. 24-27, (1991).
Pavlenko V. S. et al., "Effect of a Drug Isolated From the Heart on Biologic Energy of Cardiomyocytes in Hypoxia and Ischemia," Patol. Fiziol. Eksp. Ter., (Russia), vol. 2, pp. 20-24, (1992).
Selye H. et al., "Simple Techniques for the Surgical Occlusion of Coronary Vessels in the Rat," Angiology, vol. 11, pp. 398-407, (1960).
Small R. C. et al., "Potassium Channel Opening Drugs and the Airways," Brazilian J. Med. Biol. Res., vol. 25, No. 10, pp. 983-998, (1992).
Spatola, Arno F., "Peptide Backbone Modifications: a Structure-Activity Analysis of Peptides Containing Amide Bond Surrogates, Conformational Constraints," Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, vol. 7, Chapter 5, Editor Boris Weinstein, eds. 1983, pp. 267-357, (1983).
Spatola, A. F., "Structure-Activity Relationships of Enkephalins Containing Serially Replaced Thiomethylene Amide Bond Surrogates," Life Science, vol. 38, pp. 1243-1249, (1986).
Veber and Freidinger, "The Design of Metabolically-Stable Peptide Analogs," TINS, pp. 392-396, (Sep. 1985).
Woollard et al., "Inosine as a Selective Inotropic Agent on Ischaemic Myocardium," Cardiovasc. Res., vol. 15, pp. 659-667, (1981).
CA: 68; 47156z, Schleifer et al., 1968.
CA: 79; 124120q; Goldman, 1973.
CA: 118; 81406s; Wipf et al., 1993.
Green Lawrence R.
Maslennikov Sergei V.
Rakhilov Alexi M.
Sinackevich Nickolai V.
Criares Theodore J.
Cytran, Inc.
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