Peptides having peptidyl transferase inhibiting activity and met

Details Peptides having peptidyl transferase inhibiting activity and met Peptides having peptidyl transferase inhibiting activity and met

1993-07-20

1995-03-28

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

530328, 530329, 530330, 514 16, 514 17, C12N 900, A61K 3700, A61K 3702, C07K 500

Patent

active

054016487

ABSTRACT:
5-mer and 8-mer polypeptides have been demonstrated to inhibit peptidyl transferase and according constitutes synthetic antibiotics. Identified, sequence-specific peptides effective include

REFERENCES:
Stokes et al, Plasmid vol. 26 pp. 10-19 (1991).
Namrath et al, Mol. Gen. Genet. vol. 223 pp. 65-75 (1990).
Chen et al, J. Biol. Chem, vol. 265 pp. 3161-3167 (1990).
Bruckner et al, EMBO J. vol. 4 pp. 2295-2300 (1985).
Skovgaard et al, J. Bact. vol. 169 pp. 3976-3981 (1987).

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