Peptides having ligand activities on APJ that is an orphan G...

Details Peptides having ligand activities on APJ that is an orphan G... Peptides having ligand activities on APJ that is an orphan G...

2001-03-22

2009-12-22

Russel, Jeffrey E (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C514S002600, C514S014800, C514S015800, C530S300000, C530S328000

Reexamination Certificate

active

07635751

ABSTRACT:
The present invention relates to novel peptide derivatives, which are recognized as ligands to G-coupled protein receptor proteins.The peptide of the present invention can be used in (1) development of a receptor binding assay system using the expression system of the recombinant receptor protein and screening of candidates for pharmaceutical compounds, and (2) development of pharmaceutical preparations such as a neutral nerve function regulator, a circulatory function regulator, a cardiac function regulator, an immune function regulator, a digestive organ function regulator, a metabolic function regulator, a generative organ regulator or the like.

REFERENCES:
patent: 6475718 (2002-11-01), Doms et al.
patent: 6492324 (2002-12-01), Hinuma et al.
patent: WO 94/12635 (1994-06-01), None
patent: WO 99/33976 (1999-07-01), None
patent: WO 00/18793 (2000-04-01), None
Nishizawa et al. High Potency Analogs of Apelin, a Ligand of Orphan GPCR APJ. Peptide Science 2000. 37th, pp. 151-154.
Tatemoto et al. The novel peptide apelin lowers blood pressure . . . Regulatory Peptides. 2001, vol. 99, pp. 87-92.
Cayabyab, et al. “Apelin, the Natural Ligand of the Orphan Seven-Transmembrane Receptor APJ, Inhibits Human Immunodeficiency Virus Type I Entry”. Journal of Virology 74(24):11972-11976 (Dec. 2000).
Zou, et al. “Apelin peptides block the entry of human immunodeficiency virus (HIV)”. FEBS Lett 473:15-18 (2000).
Tatemoto, et al. “Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor”. BBRC 251:471-476 (1998).
O'Dowd, et al. “A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11”. GENE 136:355-360 (1993).

Affiliated with

Also associated with

Rating

Peptides having ligand activities on APJ that is an orphan G... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides having ligand activities on APJ that is an orphan G..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides having ligand activities on APJ that is an orphan G... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4060839