Peptides having LH-RH/FSH-RH activity

Details Peptides having LH-RH/FSH-RH activity Peptides having LH-RH/FSH-RH activity

1975-08-07

1977-05-17

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125LH, A61K 3700, C07C10352

Patent

active

040242480

ABSTRACT:
The present invention relates to peptides having strong LH-RH/FSH-RH activity, wherein Gly in the 6-position is replaced by different substituted amino acids and in the 10-position there is glycinamide or glycine in the 10-position is replaced by a NH-alkyl group with 1-3 carbon atoms or a NH-cyclopropyl group. The invention relates as well to a process for manufacturing said peptides, and to pharmaceutical preparations containing said peptides.

REFERENCES:
patent: 3896104 (1975-07-01), McKinely et al.
patent: 3901872 (1975-08-01), McKinely et al.
patent: 3914412 (1975-10-01), Gendrich et al.
Fujino et al, Biochem. Biophys. Res. Comm., 57, pp. 1248-1256, (1974).

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