Peptides having insulin autoantibody but not insulin receptor bi

Details Peptides having insulin autoantibody but not insulin receptor bi Peptides having insulin autoantibody but not insulin receptor bi

1994-03-14

1995-06-06

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 530303, 530345, A61K 3828, A61K 3800, C07K 1400

Patent

active

054223393

ABSTRACT:
A therapeutic agent that includes a purified peptide bound to a cytotoxic moiety, the peptide being specifically reactive with human insulin autoantibodies and non-reactive with human insulin cell surface receptor, is disclosed.

REFERENCES:
Arslanian et al., "Correlates of Insulin Antibodies in Newly Diagnosed Children with Insulin-dependent Diabetes Before Insulin Therapy", Diabetes, vol. 34, pp. 926-930, (1985).
Atkinson et al., "Are Insulin Autoantibodies Markers for Insulin-Dependent Diabetes Mellitus?", Diabetes, vol. 35, pp. 894-898, (1986).
Baekkeskov et al., "Identification of the 64K autoantigen in Insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase", Nature, vol. 347, pp. 151-156, (1990).
Baekkeskov et al., "Autoantibodies in Newly Diagnosed Diabetic Children Immunoprecipitate Human Pancreatic Islet Cell Proteins", Nature, vol. 298, pp. 167-169, (1982).
Benson et al., "Insulin Antibodies in Patients Receiving Penicillamine", The American Journal Of Medicine, vol. 78, pp. 857-860, (1985).
Berson et al., "Quantitative Aspects of the Reaction Between Insulin and Insulin-Binding Antibody", The Journal of Clinical Investigation, vol. 38, pp. 1996-2016, (1959).
Blundell et al., "Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology", Advances in Protein Chemistry, vol. 26, pp. 279-286, (1972).
Bottazzo et al., "Immunology and Diabetes Workshops: Report of the First International Workshop on the Standardization of Cytoplasmic Islet Cell Antibodies", Diabetologia, vol. 29, pp. 125-126, (1986).
Bottazzo et al., "Islet-Cell Antibodies in Diabetes Mellitus with Autoimmune Polyendocrine Deficiencies", The Lancet, vol. 2, pp. 1279-1283, (1974).
Bromer et al., "Preparation and Characterization of Desoctapeptide-Insulin", Biochim. Biophys. Acta, vol. 133, pp. 219-223, (1967).
Bruining et al., "Ten-Year Follow-Up Study of Islet-Cell Antibodies and Childhood Diabetes Mellitus", The Lancet, vol. 1, pp. 1100-1103, (1989).
Castano et al., "Identification and Cloning of a Granule Autoantigen (Carboxypeptidase-H) Associated with Type I Diabetes", J. Clin. Endo. Metab. vol. 73, No. 6, pp. 1197-1201, (1991).
Cho et al., "Spontaneous Hypoglycemia and Insulin Autoantibodies in a Patient with Graves Disease", Diabetes Res. Clin. Prac., Vol. 3, pp. 119-124, 1987).
Christgau et al., "Pancreatic .beta. Cells Express Two Autoantigenic Forms of Glutamic Acid Decarboxylase, a 65-kDa Hydrophilic Form and a 64-kDa Amphiphilic Form Which Can Be Both Membrane-bound and Soluble", Journal of Biological Chemistry, vol. 266, No. 31, pp. 21257-21264, (1991).
Darnell et al., "Insulin and Glucagon: Hormonal Regulation of Blood Glucose Levels", Molecular Cell Biology, Scientific American Books, Inc. New York, pp. 693-698, (1986).
Dean et al., "Insulin Autoantibodies in the Pre-diabetic Period: Correlation with Islet Cell Antibodies and Development of Diabetes", Diabetologia, vol. 29, pp. 339-342, (1986).
Diaz et al., "Differences in Epitope Restriction of Autoantibodies to Native Human Insulin (IAA) and Antibodies to Heterologous Insulin (IA)", Diabetes, vol. 36, pp. 66-72, (1987).
Gammeltoft et al., "Insulin Receptors: Binding Kinetics and Structure-Function Relationship of Insulin", Physiol. Rev., vol. 64, pp. 1321-1326, (1984).
Goldman et al., "Characterization of Circulating Insulin and Proinsulin-Binding Antibodies in Autoimmune Hypoglycemia", The American Society for Clinical Investigation, vol. 63, pp. 1050-1059, (1979).
Hirata and Ishizu, "Elevated Insulin-Binding Capacity of Serum Proteins in a Case of Spontaneous Hypoglycemia and Mild Diabetes Not Treated with Insulin", Tohoku J. Exp. Med., vol. 107, pp. 277-286, (1972).
Karjalainen et al., "Relation Between Insulin Antibody and Complement-Fixing Islet Cell Antibody at Clinical Diagnosis of IDDM", Diabetes, vol. 35, pp. 620-622, (1986).
Katsoyannis et al., "Studies on the Synthesis of Insulin from Natural and Synthetic A and B Chains; Splitting of Insulin and Isolation of the S-sulfonated Derivatives of the A and B Chains", Biochemistry, vol. 6, No. 9, pp. 2635-2642, (1967).
Kurtz et al., "Circulating Insulin-Binding Antibodies", Diabetologia, vol. 19, pp. 329-334, (1980).
Larsson et al., "Pancreatic Hormones are Expressed on the Surfaces of Human and Rat Islet Cells Through Exocytotic Sites", European Journal of Cell Biology, vol. 48, pp. 45-51, (1989).
Munson and Rodbard, "Ligand: A Versatile Computerized Approach for Characterization of Ligand-binding Systems", Anal Biochem., vol. 107, pp. 220-239, (1980).
Palmer et al., "Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment", Science, vol. 222, pp. 1337-1339, (1983).
Pietropaolo et al., "Molecular Cloning and Characterization of a Novel Neuroendocrine Autoantigen (PM-1) Related to Type I Diabetes", Diabetes, vol. 41, supplement 1, Abstr. No. 356, pp. 98A, (1992).
Pullen et al., "Receptor-Binding Region of Insulin", Nature, vol. 259, pp. 369-373, (1976).
Rodbard et al., "Quantitative Characterization of Hormone Receptors", Cancer, vol. 46, pp. 2907-2918, (1980).
Roep et al., "T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes", The Lancet, vol. 337, pp. 1439-1441, (1991).
Rudinger, "Characteristics of the amino acids as components of a peptide hormone sequence", Peptide Hormones, Edited by J. A. Parsons, National Institute for Medical Research, Mill Hill, London University Park Press, pp. 1-7, (1976).
Seino et al., "Characterization of Circulating Insulin in Insulin Autoimmune Syndrome", Journal of Clinical Endocrinology and Metabolism, vol. 62, pp. 64-69, (1986).
Sklenar et al., "Spontaneous Hypoglycemia Associated with Autoimmunity Specific to Human Insulin", Diabetes Care, vol. 10, pp. 152-159, (1978).
Soeldner et al., "Insulin-Dependent Diabetes Mellitus and Autoimmunity: Islet-Cell Autoantibodies, Insulin Autoantibodies, and Beta-Cell Failure", New England Journal Of Medicine, vol. 313, pp. 893-894, (1985).
Srikanta et al., "Autoimmunity to Insulin, Beta Cell Dysfunction, and Development of Insulin-dependent Diabetes Mellitus", Diabetes, vol. 35, pp. 139-142, (1986).
Vardi et al., "Prospective Evaluation of Subjects at High Risk for Development of Type I Diabetes Mellitus", Diabetes, vol. 36, pp. 1286-1291, (1987).
Vardi et al., "Concentration of Insulin Autoantibodies at Onset of Type I Diabetes Inverse Log-Linear Correlation with Age", Diabetes Care, vol. 11, pp. 736-739, (1988).
Wilkin et al., "Value of Insulin Antibodies as Serum Markers for Insulin Dependent Diabetes Mellitus", The Lancet, vol. 2, pp. 480-482, (1985).
Yoshimasa et al., "A New Approach to the Detection of Autoantibodies Against Insulin Receptors that Inhibit the Internalization of Insulin into Human Cells", Diabetes, vol. 33, pp. 1051-1054, (1984).
Ziegler et al., "Life-Table Analysis of Progression to Diabetes of Anti-Insulin Autoantibody-Positive Relatives of Individuals with Type I Diabetes", Diabetes, vol. 38, pp. 1320-1325, (1989).
Steinberger, I. et al. (1991) J. NeuroImmunol. Suppl. 1, p. 59 "Antigen Toxin Chimeric Proteins".
Pastan, I. & Fitz Gerald, D., J. Biol. Chem. 264, 15157-15160 (1989) "Pseudomonas Exotoxin: Chimeric Toxins" All pages.
Olsnes, S. and Pihl, A. (1982) Pharmac. Ther. 15, 355-381 "Chimeric Toxins", All pages.
FitzGerald, D. and Pastan, I. (1989) J. Natl. Cancer. Inst. 81, 1455-1463 "Targeted Toxin Therapy for the Treatment of Cancer", All pages.
Murphy, J. R. (1988) "Immunotoxins" (Frankel, A. E. ed.) Ch. 9, Klower, pp. 123-140 "Diphtheria-related peptide hormane . . . ".
Rudinger, Peptide Hormones (Ed. Parsons) Jun. 1976, pp. 1-7.
Yoshimasa et al., Diabetes vol. 33 (Nov. 1984) pp. 1051-1054.
Baekkeskov et al., 1990, Nature 347:151-156.
Christgau et al., 1991, Journal of Biological Chemistry 266:21257-21264.
Castano et al., 1991, J. Clin. Endo. Metab. 73:1197-1201.
Pietropaolo et al., 1992, Diabetes 41, supplement 1:98A. (Abstr.).
Roep et al., 1991, Lancet 337:1439-1441.

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