Peptides having ANF activity

Details Peptides having ANF activity Peptides having ANF activity

1990-08-23

1991-10-15

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530317, 530325, 530326, A61K 3702, C07K 708, C07K 710

Patent

active

050576038

ABSTRACT:
Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: ##STR1## wherein X is L-Ile, D-Ile, D-allo-Ile, L-Met or D-Met, Y is Gly, L-Ala or D-Ala, A is optionally absent or is Ser, Ser-Ser, Arg-Ser-Ser, Arg-Arg-Ser-Ser, Leu-Arg-Arg-Ser-Ser or Ser-Leu-Arg-Arg-Ser-Ser and B is optionally absent or is Asn, Asn-Ser, Asn-Ser-Phe, Asn-Ser-Phe-Arg, or Asn-Ser-Phe-Arg-Tyr, provided that at least one of Y.sup.10, Y.sup.16, Y.sup.20 or Y.sup.22 is Ala or D-Ala, and the amides, lower alkyl esters and the physiologically acceptable metal salts and acid addition salts thereof.

REFERENCES:
patent: 4670540 (1987-06-01), Sakakibara
patent: 4716147 (1987-12-01), Tjoeng et al.
patent: 4721704 (1988-01-01), Chang et al.
patent: 4764504 (1988-08-01), Johnson et al.
patent: 4861755 (1989-08-01), Breipohl et al.
Shiba et al., (Ed.), Pepptide Chemistry 1987, pp. 502-506, Protein Research Foundation, Osaka, 1987.
Rivier et al., (Ed.) Peptides: Chemistry, Structure and Biology, 1990, pp. 258-259, ESCOM, Leiden, 1990.

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