Peptides for vaccinating against human CMV

Details Peptides for vaccinating against human CMV Peptides for vaccinating against human CMV

2006-05-09

2006-05-09

Mosher, Mary E. (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S007240, C435S320100, C530S326000, C530S327000, C530S328000, C536S023720

Reexamination Certificate

active

07041442

ABSTRACT:
The present invention relates to peptides or peptide derivatives of the 65 kD lower matrix phoshpoprotein of human cytomegalovirus. The peptides disclosed are useful for determining whether subjects have been exposed to human cytomegalovirus. Methods for using these peptides or derivatives thereof to determine the peptide-induced production of interferon-γ and/or TNF-α in CD8+T cells isolated from subjects are also disclosed.

REFERENCES:
Belz et al (PNAS 95:13812-13817, 1998).
Gonczol et al (Expert Opinion on Biological Therapy, 1:401-412, 2001).
Gautier et al (European Journal of Immunology 26:1110-1117, 1996).
Alp et al (Journal of Virology 65:4812-4820, 1991).
Berencsi et al (Vaccine 14:369-374, 1996).
He et al (Journal of General Virology 76:1603-10, 1995).

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