Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-06-20
1998-11-24
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241881, 4241841, 4242041, 530324, A61K 3921, A61K 3800, A61K 3900, C07K 500
Patent
active
058403132
ABSTRACT:
Novel peptides are disclosed which correspond to epitopes of the HIV-1 gp120 protein. These antigenic peptides induce antibody-dependent cellular cytotoxicity against HIV, and thus are useful in immunization against HIV infection and induction of a heightened immune response to HIV.
REFERENCES:
"HIV Binding to the CD4 Molecule: Conformation Dependence and Binding Inhibition Studies" McDougal, et al., Human Retrovirues, Cancer and AIDS: Approaches to Prevention & Therapy, pp. 269-281 (1988).
"Polyvalent Human Immunodeficiency Virus Synthetic Immunogen Comprised of Envelope gp120 T Helper Cell Sites and B Cell Neutralization Epitopes".
Palker, et al., Journal of Immunology, 142:3612-3619, No. 10 (May 15, 1989).
"Jitters Jeopardize AIDS Vaccine Trials" Cohen, Science, 262:980-981 (Nov. 12, 1993).
"Comparative Analysis of HIV-Specific CTL Activity in Lymphoid Tissue and Peripheral Blood" Butini, et al., Journal of Cellular Biochemistry, Supplement 18B, J306, p. 147 (Jan. 21-Feb. 13, 1994).
Ho, et al, 1988, "Second Conserved Domain . . . " Science 239:1021-1023.
Haynes, 1993, "Scientific and Social Issues . . . " Science 260: 1279-1286.
Fox, 1994, "No Winners Against AIDS" Biotechnology 12:128.
Horal Peter
Jeansson Stig
Rymo Lars
Syennerholm Bo
Vahlne Anders
Smith Lynette F.
Syntello Vaccine Development KB
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