Peptides for the diagnosis of schizophrenia

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C436S503000, C424S185100

Reexamination Certificate

active

10472582

ABSTRACT:
Short peptides are provided, which bind to a body fluid sample obtained from a schizophrenic patient at a substantively higher level than to a body fluid sample obtained from a non-schizophrenic individual. The peptides are no more than 10 amino acids long and comprise a continuous sequence of at least 5 amino acids which consists of at least one positively charged amino acid at one of its ends. The provided peptides, which are the putative binding sites of autoantibodies found in high levels in schizophrenic individuals, are thus useful in diagnosis of schizophrenia.

REFERENCES:
patent: 6008001 (1999-12-01), Shinitzky
patent: WO 92/18644 (1992-10-01), None
patent: WO 95/12685 (1995-05-01), None
patent: WO 95/23970 (1995-09-01), None
patent: WO 99/30163 (1999-06-01), None
patent: WO 99/51725 (1999-10-01), None
patent: WO 00/06723 (2000-02-01), None
UniProt Q9SVH3, internet printout from Oct. 31, 2006.
Vermuyten, K. et al. “Detection of neuron specific enolase concentrations in cerebrospinal fluid from patients with neurological disorders by means of a sensitive enzyme immunoassay”,Clinica Chimica Acta, Elsevier Science Publishers B.V., vol. 187 pp. 69-78, 1990.
Deckmann, M. et al. “A conformational epitope which detects autoantibodies from schizophrenic patients”,Clinica Chimica Acta, Elsevier Science B.V., vol. 322 pp. 91-98, 2002.
Shinitzky, M. et al. “Platelet Autoantibodies in Dementia and Schizophrenia”, Ann. NY Acad. Sci., vol. 621 pp. 205-217, 1991.
Rotman, A. “Blood Platelets in Psychopharmacological Research”,Prog. Neuro-Psychopharmacol&Biol. Psychiat., Pergamon Press ltd., vol. 7 pp. 135-151, (1983).
Deckmann, M. et al. “Humoral and cellular response against autologous platelets in schizophrenia. Clinical and pathophysiological implications”,The Italian Journal of Psychiatry and Behavioral Sciences, Idelson Scientific Publications, vol. 6(2) pp. 29-34, (1996).
Carpenter, W. et al. “Schizophrenia”,The New England Journal of Medicine, vol. 330(10) pp. 681-690, (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Peptides for the diagnosis of schizophrenia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides for the diagnosis of schizophrenia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides for the diagnosis of schizophrenia will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3910588

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.