Peptides for neutralizing the toxicity of Lipid A

Details Peptides for neutralizing the toxicity of Lipid A Peptides for neutralizing the toxicity of Lipid A

1993-07-26

1997-07-29

Russell, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 514 15, 514 16, 514 17, 530324, 530327, 530328, 530329, 530350, 530317, A61K 3808, A61K 3810, A61K 3816, C07K 706

Patent

active

056522118

ABSTRACT:
The present invention is concerned with a peptide composition which includes a peptide having units of the formula:
(a) (A).sub.n wherein A is Lysine or Arginine and n is an integer with a minimum value of 7.
(b) (AB).sub.m wherein A is Lysine or Arginine and B is a hydrophobic amino acid selected from the group consisting of Valine, Leucine, Isoleucine, Tyrosine, Phenylalanine and Tryptophan; m is an integer with a minimum value of 3; and
(c) (ABC).sub.p wherein A is a cationic amino acid which Is Lysine or Arginine; B and C are hydrophobic amino acids which may be the same or different and are selected from the group consisting of Valine, Leucine, Isoleucine, Tyrosine, Phenylalanine and Tryptophan; p is an integer with a minimum value of 2. The compositions of the invention bind Lipid-A of endotoxins.

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patent: 5358933 (1994-10-01), Porro
patent: 5371186 (1994-12-01), Porro
Peptides, vol. 14, issued 1993, Mohri et al, "Synthetic Peptides Inhibit The Interaction of von Willebrand . . . ", pp. 125-129.
Science, vol. 259, Jan. 1993, Alessandro Rustici et al., "Molecular Mapping and Detoxification of the Lipid A Binding Site by Synthetic Peptides", pp. 361-365.
Merrick et al, Biochimica et Biophysica Acta vol. 1050 pp. 235-240 (1990).
Weber et al, J. Biol. Chem. vol. 263 pp. 11421-11425 (1988).
Simmons et al, Blood vol. 73 pp. 284-289 (1989).
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