Peptides for inducing cytotoxic T lymphocyte responses to hepatt

Details Peptides for inducing cytotoxic T lymphocyte responses to hepatt Peptides for inducing cytotoxic T lymphocyte responses to hepatt

1995-04-04

1998-07-14

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241541, 4241851, 4241861, 4241931, 42419611, 4242041, 4242271, 514 2, 514 15, 530300, 530327, 530328, 530403, A61K 3929, A61K 3912, A61K 39385, C07K 706

Patent

active

057800367

ABSTRACT:
Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV polymerase, and are particularly useful in treating or preventing HBV infection, including methods for stimulating the immune response of chronically infected individuals to respond to HBV antigens.

REFERENCES:
patent: 4235877 (1980-11-01), Fullerton
patent: 4428941 (1984-01-01), Galibert et al.
patent: 4487715 (1984-12-01), Nitecki
patent: 4599230 (1986-07-01), Milich et al.
patent: 4599231 (1986-07-01), Milich et al.
patent: 4818527 (1989-04-01), Thornton et al.
patent: 4882145 (1989-11-01), Thorton et al.
patent: 4935235 (1990-06-01), Rutter et al.
patent: 5017558 (1991-05-01), Vyas
patent: 5019386 (1991-05-01), Machida et al.
patent: 5039522 (1991-08-01), Neurath
patent: 5100662 (1992-03-01), Bolcsak et al.
Celis et al., "Recognition of Hepatitis B Surface Antigen by Human Lymphocytes" J. Immunol. 140:1808-1815 (Mar. 15, 1988).
Carbone et al. "Induction of Cytotoxic T Lymphocytes by Primary in vitro Stimulation with Peptides", J. Exp. Med., 167:1767-1779 (Jun. 1988).
Moore et al., "Introduction of Soluble Protein into the Class I Pathway of Antigen Processing and Presentation", Cell 54:777-785 (Sep. 9, 1988).
Milich et al., "Comparative Immunogenicity of Hepatitis B Virus Core and E Antigens", J. Immunol. 141:3617-3624 (Nov. 15, 1988).
Gotch et al., "Recognition of Influenza A Matrix Protein by HLA-A2-Restricted Cytotoxic T Lymphocytes", J. Exp. Med. 163:2045-2057 (Dec. 1988).
Milich, "T-and B-cell Recognition of Hepatitis B Viral Antigens", Immunol. Today 9:380-386 (1988).
Hayashi et al., "Studies on Peptides CLXVI. Solid-Phase Synthesis and Immunological Properties of Fragment Peptides Related to Human Hepatitis B virus Surface Antigen (HBsAg) and Its Pre-S2 Gene" Chem. Pharm. Bull. 36(12):4993-4994 (1988).
Braciale et al., "Class I Major Histocompatibility Complex-restricted Cytolytic T Lymphocytes Recognize a Limited Number of sites on the Influenza Hemagglutinin", Proc. Natl. Acad. Sci. USA 86:277-281 (Jan. 1989).
Ishioka et al., "Induction of Class I MHC-restricted, Peptide-specific Cytolytic T Lymphocytes by Peptide Priming in vivo", J. Immonol., 143:1094-1100 (Aug. 15, 1989).
Klavinskis et al., "Molecularly Engineered Vaccine Which Expresses an Immunodominant T-cell Epitope Induces Cytotoxic T Lymphocytes that Confer Protection for Lethal Virus Infection," J. Virol., 63:4311-4316 (Oct. 1989).
Bevan, "Stimulating Killer Cells", Nature 342:478-479 (Nov. 30, 1989).
Deres et al., "In Vivo Priming of Virus-Specific Cytotoxic T Lymphocytes with Synthetic Lipopeptide Vaccine", Nature 342:561-564 (Nov. 30, 1989).
Tam et al., "Vaccine Engineering: Enhancement of Immunogenicity of Synthetic Peptide Vaccines Related to Hepatitis in Chemically Defined Models Consisting of T-and B-cell Epitopes", Proc. Natl. Acad. Sci. USA 86:9084-9088 (Dec. 1989).
Chisari et al., "Hepatitis B Virus Structure and Biology", Microbial Pathogenesis 6:311-325 (1989).
Moriyama et al., "Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice", Science 248:361-364 (Apr. 20, 1990).
Aichele et al., "Antiviral Cytotoxic T Cell Response Induced by in vivo Priming with a Free Synthetic Peptide", J. Exp. Med., 171:1815-1820 (May, 1990).
Aggarwal et al., "Oral Salmonella: Malaria Circumsporozoite Recombinants Induce Specific CD8+ Cytotoxic T Cells", J. Exp. Med., 172:1083-1090 (Oct. 1990).
Van Bleek et al., "Isolation of an Endogenously Processed Immunodominant Viral Peptide from the Class IH-2K.sup.b Molecule", Nature 348:213-216 (Nov. 15, 1990).
Rotzschke et al., "Isolation and Analysis of Naturally Processed Viral Peptides as Recognized by Cytotoxic T cells", Nature 348:252-254 (Nov. 15, 1990).
Golvano et al., "Polarity of Immunogens: Implications for Vaccine Design", Eur. J. Immunol. 20:2363-2366 (1990).
Ishioka et al., "Class I MHC-restricted, Peptide-specific Cytotoxic T Lymphocytes Generated by Peptide Priming in vivo", Vaccines 90, Cold Spring Harbor Press, pp. 7-11 (1990).
Wakita et al "Gamma-Interferon Production Response to Hepatitis B Core Protein & Synthetic Peptides in Patients with Chronic Hepatitis B Virus Infection", Digestion 47:149-155 (1990).
Kast et al., "Protection Against Lethal Sendai Virus Infection by in vivo Priming of Virus-specific Cytotoxic T Lymphocytes with a Free Synthetic Peptide", Proc. Natl. Acad. Sci. USA 88:2283-2287 (Mar. 1991).
Schumacher et al., "Peptide Selection by MHC Class I Molecules" Nature 350:703-706 (Apr. 25, 1991).
Falk et al., "Allele-specific Motifs Revealed by Sequencing of Self-peptides Eluted from MHC Molecules", Nature 351:290-296 (May 23, 1991).
Ferrari et al., "Identification of Immunodominant T Cell Epitopes of the Hepatitis B Virus Nucleocapsid Antigen", J. Clin. Invest., 88:214-222 (Jul. 1991).
Bertoletti, "HLA Class I-restricted Human Cytotoxic T Cells Recognize Endogenously Synthesized Hepatitis B Nucleocapsid Antigen", Proc. Natl. Aad/ Sci. USA 88:10445-10449 (Dec. 1991).
Penna et al., "Cytotoxic T Lymphocytes Recognize an HLA-A2-restricted Epitope Within the Hepatitis B Virus Nucleocapsid Antigen", J. Exp. Med. 174:1565-1570 (Dec. 1991).
Sarobe et al. "Induction of Antibodies Against Peptide Hapten Does Not Require Covalent Linkage Between Hapten & Class II Presentable T Helper Peptide", Eur. J. Immunol. 21:1555-15558 (1991).
Cassell et al., "Linked Recognition of Helper and Cytotoxic Antigenic Determinants for the Generation of Cytotoxic T Lymphocytes", Ann. N.Y. Acad. Sci., pp. 51-60 (1991).
Penna et al., "Hepatitis B Virus HBV-Specific Cytotoxic T Cell (CTL) Response in Humans: Characterization of HLA Class II-Restricted CTLs That Recognize Endogenously Synthesized HBV Envelope Antigens", J. Virol. 66:1193-1198 (Feb. 1992).
Guilhot et al., "Hepatitis B Virus (HBV) -Specific Cytotoxic T-Cell Response in Humans: Production of Target Cells by Stable Expression of HBV-Encoded Proteins in Immortalized Human B-Cell Lines", J. Virol. 66:2670-2678 (May 1992).
Bhatnagar et al., "Immune Response to Synthetic Peptide Analogues of Hepatitis B Surface Antigen Specific for the Determinant" Proc. Natl. Acad. Sci. USA 79:4400-44-4 (Jul. 1982).
Mondelli et al., "Specificity of T Lymphocyte Cytotoxicity to Autologous Hepatocytes in Chronic Hepatitis B Virus Infection: Evidence that T Cells are Directed Against HBV Core Antigen Expressed on Hepatocytes", J. Immunol., 129:2773-2778 (Dec. 1982).
von Boehmer et al., "Autonomously Proliferating K/D-restricted Cytolytic T Cell Clones", Eur. J. Immunol. 13:176-179 (1983).
Neurath et al., "Specificity of Antibodies Elicited by a Synthetic Peptide having a Sequence in Common with a Fragment of a Virus Protein --The Hepatitis B Surface Antigen", Develop. Biol. Standard, 54:103-112 (1983).
von Boehmer et al., "Lyt-2 Cell-Independent Functions of Lyt-2+ Cells Stimulated with Antigen or Concanavalin A", J. Immunol., 133:59-64 (Jul. 1984).
Hopp, "Immunogenicity of a synthetic HBsAg Peptide: Enhancement by Conjugate to a Fatty Acid Carrier", Molecular Immunol. 21:13-16 (1984).
Milich et al., "Immunogenetics and Cellular Correlates of the Immune Response to Hepatitis B Surface Antigen Determinants", Adv. Hepatitis Res. Masson, NY, NY USA 91-109 (1984).
Fujii et al., "Peptide Chemistry 1983" published 1984 by Protein Research Foundation (OSAKA) , pp. 215-220.
Sprent et al., "Properties of Purified T Cell Subsets", J. Exp. Med., 162:2068-2088 (Dec. 1985).
Townsend et al., "The Epitopes of Influenza Nucleoprotein Recognized by Cytotoxic T Lymphocytes Can Be Defined with Short Synthetic Peptides", Cell 44:959-968 (Mar. 28, 1986).
Bessler et al., "The Syntheitc Analog of Bacterial Lipoprotein are Potent Immunoadjuvants in Combination with or Covalently Linked to Antigen", Prog. Leukocyte Biol. 5:337-344 (1986).
Watari et al., "A Synthetic Peptide Induces Long -Term Protection from Lethal Infection with Herpes Simplex Virus 2", J. Exp. Med., 165:459-470 (Feb. 1987).
Gotch et al., "Cytotoxic T Lymphocytes Recognize a

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