Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-06-05
1998-08-04
Woodward, Michael P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241541, 4241551, 4241861, 4241931, 42419611, 4242041, 4242271, 514 2, 514 75, 530300, 530328, 930220, 930223, A61K 3929, A61K 3912, A61K 39385, C07K 706
Patent
active
057889694
ABSTRACT:
Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV envelope, and are particularly useful in treating or preventing HBV infection, including methods for stimulating the immune response of chronically infected individuals to respond to HBV antigens.
REFERENCES:
Hilleman, "comparative Biology and Pathogenesis of AIDS and Hepatitis B Viruses: Related but Different", AIDS Res. Hum. Retrovir. 10, 1409-1419 (1994).
Nayersina et al., "HLA A2 Restricted Cytotoxic T Lymphocyte Responses to Multiple Hepatitis B Surface Antigen Epitopes during Hepaittis B Virus Infection", J. Immunol. 150, 4659-4671 (1991).
Celis et al., "Recognition of Hepatitis B Surfaces Antigon . . . ," J Immunol 140:1808-1815 (1988).
The Scripps Research Institute
Woodward Michael P.
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