Peptides for inducing apoptosis in tumor cells

Details Peptides for inducing apoptosis in tumor cells Peptides for inducing apoptosis in tumor cells

2003-07-01

2009-06-09

Goddard, Laura B (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C514S002600

Reexamination Certificate

active

07544768

ABSTRACT:
The present invention relates to peptides which interact with IAPs. IAPs are highly expressed in tumor cells which fail to undergo apoptosis. By binding to IAPs, the peptides of the present invention release tumor cells from the apoptosis block and thus provide a new tool for effective cancer therapy.

REFERENCES:
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patent: WO 02/16402 (2002-02-01), None
patent: WO 02/26775 (2002-04-01), None
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Dermer (Bio/Technology, 1994, 12:320) t.
Zips et al (2005, In Vivo, 19:1-7).
Examination of Patent Applications Containing Nucleotide Sequences, p. 1-3.
Franklin et al, Biochemistry, 2003, 42:8223-8231.
Wang et al, Cancer Gene Therapy, 2008, 15:402-412.

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